Neutrophil extracellular traps in ischemic AKI

new way to kill

Jing Liu, Zheng Dong

Research output: Contribution to journalComment/debate

Abstract

Neutrophil extracellular traps, originally discovered as a mechanism to combat microbial infection, have recently been implicated in tissue damage including acute kidney injury. Raup-Konsavage et al. now present further insights to demonstrate a critical role of neutrophil peptidyl arginine deiminase-4 in the formation of neutrophil extracellular trap, inflammation, and tissue damage in ischemic acute kidney infection. Targeting peptidyl arginine deiminase-4 and/or neutrophil extracellular trap may offer a new therapeutic strategy for acute kidney infection.

Original languageEnglish (US)
Pages (from-to)303-305
Number of pages3
JournalKidney International
Volume93
Issue number2
DOIs
StatePublished - Feb 1 2018

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Infection
Kidney
Acute Kidney Injury
Neutrophils
Inflammation
Extracellular Traps
arginine deiminase
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Neutrophil extracellular traps in ischemic AKI : new way to kill. / Liu, Jing; Dong, Zheng.

In: Kidney International, Vol. 93, No. 2, 01.02.2018, p. 303-305.

Research output: Contribution to journalComment/debate

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