New Agents in Acute Myeloid Leukemia and Other Myeloid Disorders

Farhad Ravandi, Hagop Kantarjian, Francis Giles, Jorge Cortes

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Over the past several decades, improvements in chemotherapeutic agents and supportive care have resulted in significant progress in treating patients with acute myeloid leukemia (AML). More recently, advances in understanding the biology of AML have resulted in the identification of new therapeutic targets. The success of all-trans-retinoic acid in acute promyelocytic leukemia and of imatinib mesylate in chronic myeloid leukemia have demonstrated that targeted therapy may be more effective and less toxic when well defined targets are available. At the same time, understanding mechanisms of drug resistance and means to overcome them has led to modification of some of the existing cytotoxic agents. Rational design and conduct of clinical trials is necessary to ensure that the full potential of these new agents is realized.

Original languageEnglish (US)
Pages (from-to)441-454
Number of pages14
JournalCancer
Volume100
Issue number3
DOIs
StatePublished - Feb 1 2004
Externally publishedYes

Keywords

  • Acute myeloid leukemia
  • New agents
  • New targets
  • Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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