New approaches for treating atrial fibrillation: Focus on autonomic modulation

Daniel Sohinki, Stavros Stavrakis

Research output: Contribution to journalReview article

Abstract

Atrial fibrillation (AF) is a rapidly growing clinical problem in routine practice, both for cardiologists as well as general practitioners. Current therapies aimed at the management of AF include anti-arrhythmic drug therapy and catheter ablation. These therapies have a number of limitations and risks, and have disappointing long-term efficacy in maintaining sinus rhythm and improving hard clinical outcomes. Because of this, there is growing interest in pursuing alternative management strategies in patients with AF. This review seeks to highlight emerging AF therapies, with a specific focus on several modalities aimed at modulation of the autonomic nervous system. These therapies have shown promise in early pre-clinical and clinical trials, and represent exciting alternatives to standard AF treatment.

Original languageEnglish (US)
JournalTrends in Cardiovascular Medicine
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Atrial Fibrillation
Therapeutics
Catheter Ablation
Anti-Arrhythmia Agents
Autonomic Nervous System
General Practitioners
Clinical Trials
Drug Therapy

Keywords

  • Atrial fibrillation
  • Autonomic modulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

New approaches for treating atrial fibrillation : Focus on autonomic modulation. / Sohinki, Daniel; Stavrakis, Stavros.

In: Trends in Cardiovascular Medicine, 01.01.2019.

Research output: Contribution to journalReview article

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AB - Atrial fibrillation (AF) is a rapidly growing clinical problem in routine practice, both for cardiologists as well as general practitioners. Current therapies aimed at the management of AF include anti-arrhythmic drug therapy and catheter ablation. These therapies have a number of limitations and risks, and have disappointing long-term efficacy in maintaining sinus rhythm and improving hard clinical outcomes. Because of this, there is growing interest in pursuing alternative management strategies in patients with AF. This review seeks to highlight emerging AF therapies, with a specific focus on several modalities aimed at modulation of the autonomic nervous system. These therapies have shown promise in early pre-clinical and clinical trials, and represent exciting alternatives to standard AF treatment.

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