TY - GEN
T1 - New approaches to identify cancer heterogeneity in DNA methylation studies using the lepage test and multinomial logistic regression
AU - Lee, Seongkeon
AU - Piao, Youngjun
AU - Shi, Huidong
AU - Choi, Jeong Hyeon
N1 - Funding Information:
This work was partially supported by National Institutes of Health AA019976, CA185833, CA190429, and HL104125, Department of Defense PR110715, and Brain Korea 21.
Publisher Copyright:
© 2015 IEEE.
PY - 2015/10/16
Y1 - 2015/10/16
N2 - It is well known that cancer cells are diverse and heterogeneous among patients, and that this heterogeneity makes cancer diagnosis and cure difficult. Intra-tumoral heterogeneity has very recently become important because a small proportion of drug-resistant or tumor-initiating cells can ultimately determine a patient's outcome. In this study, we propose new approaches to use variance tests, including the Lepage test, to identify inter-patient cancer heterogeneity, as well as multinomial logistic regression to identify intra-patient cancer heterogeneity, i.e., different epiallele composition. We conduct experiments to show the performance of the proposed approaches.
AB - It is well known that cancer cells are diverse and heterogeneous among patients, and that this heterogeneity makes cancer diagnosis and cure difficult. Intra-tumoral heterogeneity has very recently become important because a small proportion of drug-resistant or tumor-initiating cells can ultimately determine a patient's outcome. In this study, we propose new approaches to use variance tests, including the Lepage test, to identify inter-patient cancer heterogeneity, as well as multinomial logistic regression to identify intra-patient cancer heterogeneity, i.e., different epiallele composition. We conduct experiments to show the performance of the proposed approaches.
UR - http://www.scopus.com/inward/record.url?scp=84953425895&partnerID=8YFLogxK
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U2 - 10.1109/CIBCB.2015.7300318
DO - 10.1109/CIBCB.2015.7300318
M3 - Conference contribution
AN - SCOPUS:84953425895
T3 - 2015 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2015
BT - 2015 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2015
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2015
Y2 - 12 August 2015 through 15 August 2015
ER -