New concepts on the pathogenesis of fever

Charles A. Dinarello, Joseph Gerard Cannon, Sheldon M. Wolff

Research output: Contribution to journalArticle

270 Citations (Scopus)

Abstract

For more than 50 years, experimental studies on fever have focused on a substance from leukocytes called leukocytic or endogenous pyrogen. Various investigators concluded that changes associated with infection-such as numbers of circulating leukocytes; levels of trace metals, amino acids, and hepatic proteins; and altered lymphocyte function-were also caused by endogenous leukocyte mediators. There was reasonable evidence that fever and these other changes were brought about through the action of a single endogenous pyrogen, now known as interleukin 1 (IL-1). Two forms of IL-1 have been cloned (IL-1 [J and IL-1 a), and studies of recombinant IL-1 preparations have confirmed that fever and the broad spectrum of host responses to infection and injury are indeed mediated by this substance. However, IL-1 is not the only leukocyte product that induces fever: Tumor necrosis factor (cachectin) and interferon produce fever in humans and animals. Accordingly, the concept of a single endogenous pyrogen now requires modification. Nature has conferred the ability to produce fever on no fewer than three structurally distinct molecules. Investigators trying to determine what triggers the hypothalamus to initiate fever in a particular disease must now consider these three endogenous pyrogens, either alone or together, as mediators of fever.

Original languageEnglish (US)
Pages (from-to)168
Number of pages1
JournalReviews of Infectious Diseases
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1988

Fingerprint

Fever
Interleukin-1
Leukocytes
Research Personnel
Infection
Leukocyte Count
Interferons
Hypothalamus
Tumor Necrosis Factor-alpha
Metals
leukocyte endogenous mediator
Lymphocytes
Amino Acids
Liver
Wounds and Injuries
Proteins

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

New concepts on the pathogenesis of fever. / Dinarello, Charles A.; Cannon, Joseph Gerard; Wolff, Sheldon M.

In: Reviews of Infectious Diseases, Vol. 10, No. 1, 01.01.1988, p. 168.

Research output: Contribution to journalArticle

Dinarello, CA, Cannon, JG & Wolff, SM 1988, 'New concepts on the pathogenesis of fever', Reviews of Infectious Diseases, vol. 10, no. 1, pp. 168. https://doi.org/10.1093/clinids/10.1.168
Dinarello, Charles A. ; Cannon, Joseph Gerard ; Wolff, Sheldon M. / New concepts on the pathogenesis of fever. In: Reviews of Infectious Diseases. 1988 ; Vol. 10, No. 1. pp. 168.
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