New insights into leukocyte recruitment by intravital microscopy

Alexander Zarbock, Klaus Ley

Research output: Chapter in Book/Report/Conference proceedingChapter

27 Scopus citations

Abstract

Leukocyte recruitment to sites of inflammation requires adhesion to and transmigration through the blood vessel wall. Recent progress in optical equipment and new genetic and molecular tools have revealed additional steps in the leukocyte adhesion cascade beyond rolling, adhesion, and transmigration. In vivo studies using intravital microscopy (IVM) were essential for the discovery of slow rolling, postadhesion strengthing, intraluminal crawling, and different routes of transmigration. IVM revealed unique features of leukocyte recruitment in different organs. This review focuses on insights into the leukocyte adhesion cascade gained by IVM.

Original languageEnglish (US)
Title of host publicationVisualizing Immunity
PublisherSpringer Verlag
Pages129-152
Number of pages24
Edition1
ISBN (Print)9783540938620
DOIs
StatePublished - 2009
Externally publishedYes

Publication series

NameCurrent Topics in Microbiology and Immunology
Number1
Volume334
ISSN (Print)0070-217X

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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