New-onset juvenile dermatomyositis

Comparisons with a healthy cohort and children with juvenile rheumatoid arthritis

Lauren M. Pachman, Jennifer R. Hayford, Marc C. Hochberg, Mark A. Pallansch, Ahn Chung, Claire D. Daugherty, Balu H. Athreya, Suzanne L. Bowyer, Chester W. Fink, Harry L. Gewanter, Rita S Jerath, Bianca A. Lang, Ilona S. Szer, James Sinacore, Mary L. Christensen, Alan R. Dyer

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objective. To determine, in a case-control study, if patients with new- onset juvenile dermatomyositis (juvenile DM) have increased symptoms prior to onset, exposure to certain environmental conditions, frequency of familial autoimmune diseases, or antibody titers, compared with 2 control groups. Methods. A structured interview with the families of 80 children with juvenile DM, 40 children with juvenile rheumatoid arthritis (JRA), or 23 healthy children, from the same geographic area as the children with juvenile DM, was conducted. All children's sera were tested for antibody to Toxoplasma gondii, herpes simplex virus (HSV), or coxsackievirus B (CVB). Results. A high proportion of children with juvenile DM had constitutional symptoms 3 months before the disease-onset date (P = 0.013 versus control children). Children with JRA had more relatives with rheumatoid arthritis (P = 0.0001) and pernicious anemia (P = 0.003) than did children with juvenile DM or healthy children. Among children ≤7 years of age, elevated enteroviral titers were more frequent in those with juvenile DM (81%) and in healthy controls (90%) than in those with JRA (64%), suggesting a common environmental exposure. Titers to T gondii, HSV, or CVB 1-6 were normal. Conclusion. Frequencies of familial autoimmune disease, exposure to environmental factors, or elevated antibody titers to T gondii, HSV, or CVB are not increased in juvenile DM. Children with juvenile DM do have symptoms of illness 3 months before the diseaseonset date, and young patients have elevated enteroviral titers, as do young geographic controls.

Original languageEnglish (US)
Pages (from-to)1526-1533
Number of pages8
JournalArthritis and Rheumatism
Volume40
Issue number8
DOIs
StatePublished - Aug 1 1997

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Juvenile Arthritis
Human Enterovirus B
Cercopithecine Herpesvirus 1
Simplexvirus
Environmental Exposure
Autoimmune Diseases
Juvenile dermatomyositis
Antibodies
Pernicious Anemia
Toxoplasma
Case-Control Studies
Rheumatoid Arthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Pachman, L. M., Hayford, J. R., Hochberg, M. C., Pallansch, M. A., Chung, A., Daugherty, C. D., ... Dyer, A. R. (1997). New-onset juvenile dermatomyositis: Comparisons with a healthy cohort and children with juvenile rheumatoid arthritis. Arthritis and Rheumatism, 40(8), 1526-1533. https://doi.org/10.1002/art.1780400822

New-onset juvenile dermatomyositis : Comparisons with a healthy cohort and children with juvenile rheumatoid arthritis. / Pachman, Lauren M.; Hayford, Jennifer R.; Hochberg, Marc C.; Pallansch, Mark A.; Chung, Ahn; Daugherty, Claire D.; Athreya, Balu H.; Bowyer, Suzanne L.; Fink, Chester W.; Gewanter, Harry L.; Jerath, Rita S; Lang, Bianca A.; Szer, Ilona S.; Sinacore, James; Christensen, Mary L.; Dyer, Alan R.

In: Arthritis and Rheumatism, Vol. 40, No. 8, 01.08.1997, p. 1526-1533.

Research output: Contribution to journalArticle

Pachman, LM, Hayford, JR, Hochberg, MC, Pallansch, MA, Chung, A, Daugherty, CD, Athreya, BH, Bowyer, SL, Fink, CW, Gewanter, HL, Jerath, RS, Lang, BA, Szer, IS, Sinacore, J, Christensen, ML & Dyer, AR 1997, 'New-onset juvenile dermatomyositis: Comparisons with a healthy cohort and children with juvenile rheumatoid arthritis', Arthritis and Rheumatism, vol. 40, no. 8, pp. 1526-1533. https://doi.org/10.1002/art.1780400822
Pachman, Lauren M. ; Hayford, Jennifer R. ; Hochberg, Marc C. ; Pallansch, Mark A. ; Chung, Ahn ; Daugherty, Claire D. ; Athreya, Balu H. ; Bowyer, Suzanne L. ; Fink, Chester W. ; Gewanter, Harry L. ; Jerath, Rita S ; Lang, Bianca A. ; Szer, Ilona S. ; Sinacore, James ; Christensen, Mary L. ; Dyer, Alan R. / New-onset juvenile dermatomyositis : Comparisons with a healthy cohort and children with juvenile rheumatoid arthritis. In: Arthritis and Rheumatism. 1997 ; Vol. 40, No. 8. pp. 1526-1533.
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abstract = "Objective. To determine, in a case-control study, if patients with new- onset juvenile dermatomyositis (juvenile DM) have increased symptoms prior to onset, exposure to certain environmental conditions, frequency of familial autoimmune diseases, or antibody titers, compared with 2 control groups. Methods. A structured interview with the families of 80 children with juvenile DM, 40 children with juvenile rheumatoid arthritis (JRA), or 23 healthy children, from the same geographic area as the children with juvenile DM, was conducted. All children's sera were tested for antibody to Toxoplasma gondii, herpes simplex virus (HSV), or coxsackievirus B (CVB). Results. A high proportion of children with juvenile DM had constitutional symptoms 3 months before the disease-onset date (P = 0.013 versus control children). Children with JRA had more relatives with rheumatoid arthritis (P = 0.0001) and pernicious anemia (P = 0.003) than did children with juvenile DM or healthy children. Among children ≤7 years of age, elevated enteroviral titers were more frequent in those with juvenile DM (81{\%}) and in healthy controls (90{\%}) than in those with JRA (64{\%}), suggesting a common environmental exposure. Titers to T gondii, HSV, or CVB 1-6 were normal. Conclusion. Frequencies of familial autoimmune disease, exposure to environmental factors, or elevated antibody titers to T gondii, HSV, or CVB are not increased in juvenile DM. Children with juvenile DM do have symptoms of illness 3 months before the diseaseonset date, and young patients have elevated enteroviral titers, as do young geographic controls.",
author = "Pachman, {Lauren M.} and Hayford, {Jennifer R.} and Hochberg, {Marc C.} and Pallansch, {Mark A.} and Ahn Chung and Daugherty, {Claire D.} and Athreya, {Balu H.} and Bowyer, {Suzanne L.} and Fink, {Chester W.} and Gewanter, {Harry L.} and Jerath, {Rita S} and Lang, {Bianca A.} and Szer, {Ilona S.} and James Sinacore and Christensen, {Mary L.} and Dyer, {Alan R.}",
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T1 - New-onset juvenile dermatomyositis

T2 - Comparisons with a healthy cohort and children with juvenile rheumatoid arthritis

AU - Pachman, Lauren M.

AU - Hayford, Jennifer R.

AU - Hochberg, Marc C.

AU - Pallansch, Mark A.

AU - Chung, Ahn

AU - Daugherty, Claire D.

AU - Athreya, Balu H.

AU - Bowyer, Suzanne L.

AU - Fink, Chester W.

AU - Gewanter, Harry L.

AU - Jerath, Rita S

AU - Lang, Bianca A.

AU - Szer, Ilona S.

AU - Sinacore, James

AU - Christensen, Mary L.

AU - Dyer, Alan R.

PY - 1997/8/1

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N2 - Objective. To determine, in a case-control study, if patients with new- onset juvenile dermatomyositis (juvenile DM) have increased symptoms prior to onset, exposure to certain environmental conditions, frequency of familial autoimmune diseases, or antibody titers, compared with 2 control groups. Methods. A structured interview with the families of 80 children with juvenile DM, 40 children with juvenile rheumatoid arthritis (JRA), or 23 healthy children, from the same geographic area as the children with juvenile DM, was conducted. All children's sera were tested for antibody to Toxoplasma gondii, herpes simplex virus (HSV), or coxsackievirus B (CVB). Results. A high proportion of children with juvenile DM had constitutional symptoms 3 months before the disease-onset date (P = 0.013 versus control children). Children with JRA had more relatives with rheumatoid arthritis (P = 0.0001) and pernicious anemia (P = 0.003) than did children with juvenile DM or healthy children. Among children ≤7 years of age, elevated enteroviral titers were more frequent in those with juvenile DM (81%) and in healthy controls (90%) than in those with JRA (64%), suggesting a common environmental exposure. Titers to T gondii, HSV, or CVB 1-6 were normal. Conclusion. Frequencies of familial autoimmune disease, exposure to environmental factors, or elevated antibody titers to T gondii, HSV, or CVB are not increased in juvenile DM. Children with juvenile DM do have symptoms of illness 3 months before the diseaseonset date, and young patients have elevated enteroviral titers, as do young geographic controls.

AB - Objective. To determine, in a case-control study, if patients with new- onset juvenile dermatomyositis (juvenile DM) have increased symptoms prior to onset, exposure to certain environmental conditions, frequency of familial autoimmune diseases, or antibody titers, compared with 2 control groups. Methods. A structured interview with the families of 80 children with juvenile DM, 40 children with juvenile rheumatoid arthritis (JRA), or 23 healthy children, from the same geographic area as the children with juvenile DM, was conducted. All children's sera were tested for antibody to Toxoplasma gondii, herpes simplex virus (HSV), or coxsackievirus B (CVB). Results. A high proportion of children with juvenile DM had constitutional symptoms 3 months before the disease-onset date (P = 0.013 versus control children). Children with JRA had more relatives with rheumatoid arthritis (P = 0.0001) and pernicious anemia (P = 0.003) than did children with juvenile DM or healthy children. Among children ≤7 years of age, elevated enteroviral titers were more frequent in those with juvenile DM (81%) and in healthy controls (90%) than in those with JRA (64%), suggesting a common environmental exposure. Titers to T gondii, HSV, or CVB 1-6 were normal. Conclusion. Frequencies of familial autoimmune disease, exposure to environmental factors, or elevated antibody titers to T gondii, HSV, or CVB are not increased in juvenile DM. Children with juvenile DM do have symptoms of illness 3 months before the diseaseonset date, and young patients have elevated enteroviral titers, as do young geographic controls.

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