Abstract
Alveolar bone grafting is an adjunctive procedure that has become increasingly popular in the rehabilitation of patients with cleft lip and palate. A histologic basis of the performance of bone grafts is required to evaluate properly different grafting materials. This, however, cannot be provided by clinical studies on humans. Therefore, an animal model with a simulated alveolar cleft is needed. A number of animal models has been previously proposed by other investigators. The problems associated with each model are presented and a surgical technique for the creation of permanent alveolar clefts in rabbits is described. Clinical and histologic findings 6 weeks postoperatively confirm the establishment of a 1-cm wide defect with oronasal communication and healthy epithelial lining. This animal model can be efficiently use for the testing of various bone grafting materials.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 542-547 |
| Number of pages | 6 |
| Journal | Cleft Palate-Craniofacial Journal |
| Volume | 30 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 29 1993 |
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ASJC Scopus subject areas
- Oral Surgery
- Otorhinolaryngology
Cite this
New technique for creating permanent experimental alveolar clefts in a rabbit model. / El-Bokle, D.; Smith, S. J.; Germane, N.; Sharawy, Mohamed M.H.
In: Cleft Palate-Craniofacial Journal, Vol. 30, No. 6, 29.11.1993, p. 542-547.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New technique for creating permanent experimental alveolar clefts in a rabbit model
AU - El-Bokle, D.
AU - Smith, S. J.
AU - Germane, N.
AU - Sharawy, Mohamed M.H.
PY - 1993/11/29
Y1 - 1993/11/29
N2 - Alveolar bone grafting is an adjunctive procedure that has become increasingly popular in the rehabilitation of patients with cleft lip and palate. A histologic basis of the performance of bone grafts is required to evaluate properly different grafting materials. This, however, cannot be provided by clinical studies on humans. Therefore, an animal model with a simulated alveolar cleft is needed. A number of animal models has been previously proposed by other investigators. The problems associated with each model are presented and a surgical technique for the creation of permanent alveolar clefts in rabbits is described. Clinical and histologic findings 6 weeks postoperatively confirm the establishment of a 1-cm wide defect with oronasal communication and healthy epithelial lining. This animal model can be efficiently use for the testing of various bone grafting materials.
AB - Alveolar bone grafting is an adjunctive procedure that has become increasingly popular in the rehabilitation of patients with cleft lip and palate. A histologic basis of the performance of bone grafts is required to evaluate properly different grafting materials. This, however, cannot be provided by clinical studies on humans. Therefore, an animal model with a simulated alveolar cleft is needed. A number of animal models has been previously proposed by other investigators. The problems associated with each model are presented and a surgical technique for the creation of permanent alveolar clefts in rabbits is described. Clinical and histologic findings 6 weeks postoperatively confirm the establishment of a 1-cm wide defect with oronasal communication and healthy epithelial lining. This animal model can be efficiently use for the testing of various bone grafting materials.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027519727&partnerID=8YFLogxK
U2 - 10.1597/1545-1569(1993)030<0542:NTFCPE>2.3.CO;2
DO - 10.1597/1545-1569(1993)030<0542:NTFCPE>2.3.CO;2
M3 - Article
C2 - 8280731
AN - SCOPUS:0027519727
VL - 30
SP - 542
EP - 547
JO - Cleft Palate-Craniofacial Journal
JF - Cleft Palate-Craniofacial Journal
SN - 1055-6656
IS - 6
ER -