New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A series of quinolone derivatives, containing different heterocyclic amines were prepared. Synthesized compounds were evaluated for their in vitro antimicrobial activities against two Gram-positive bacteria, three Gram-negative bacteria as well as four fungi. All the derivatives showed good activity towards Gram-positive bacteria and less activity towards Gram-negative bacteria. They also showed moderate to comparable activity against Aspergillus niger and Candida albicans and low to moderate antifungal activity against Aspergillus fumigatus and Aspergillus flavus.

Original languageEnglish (US)
Pages (from-to)3225-9
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number11
DOIs
StatePublished - Jun 1 2013

Keywords

  • Amines
  • Anti-Infective Agents
  • Aspergillus flavus
  • Aspergillus niger
  • Candida albicans
  • Fluorine
  • Gram-Negative Bacteria
  • Gram-Positive Bacteria
  • Microbial Sensitivity Tests
  • Quinolones
  • Journal Article
  • Research Support, Non-U.S. Gov't

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