New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A series of quinolone derivatives, containing different heterocyclic amines were prepared. Synthesized compounds were evaluated for their in vitro antimicrobial activities against two Gram-positive bacteria, three Gram-negative bacteria as well as four fungi. All the derivatives showed good activity towards Gram-positive bacteria and less activity towards Gram-negative bacteria. They also showed moderate to comparable activity against Aspergillus niger and Candida albicans and low to moderate antifungal activity against Aspergillus fumigatus and Aspergillus flavus.

Original languageEnglish (US)
Pages (from-to)3225-9
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number11
DOIs
StatePublished - Jun 1 2013

Fingerprint

Quinolones
Gram-Positive Bacteria
Gram-Negative Bacteria
Aspergillus
Bacteria
Derivatives
Aspergillus flavus
Aspergillus fumigatus
Aspergillus niger
Candida albicans
Amines
Fungi
Candida
In Vitro Techniques

Keywords

  • Amines
  • Anti-Infective Agents
  • Aspergillus flavus
  • Aspergillus niger
  • Candida albicans
  • Fluorine
  • Gram-Negative Bacteria
  • Gram-Positive Bacteria
  • Microbial Sensitivity Tests
  • Quinolones
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

@article{537d15abd74742b88814cd597975d09d,
title = "New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties",
abstract = "A series of quinolone derivatives, containing different heterocyclic amines were prepared. Synthesized compounds were evaluated for their in vitro antimicrobial activities against two Gram-positive bacteria, three Gram-negative bacteria as well as four fungi. All the derivatives showed good activity towards Gram-positive bacteria and less activity towards Gram-negative bacteria. They also showed moderate to comparable activity against Aspergillus niger and Candida albicans and low to moderate antifungal activity against Aspergillus fumigatus and Aspergillus flavus.",
keywords = "Amines, Anti-Infective Agents, Aspergillus flavus, Aspergillus niger, Candida albicans, Fluorine, Gram-Negative Bacteria, Gram-Positive Bacteria, Microbial Sensitivity Tests, Quinolones, Journal Article, Research Support, Non-U.S. Gov't",
author = "Panda, {Siva S}",
note = "Copyright {\circledC} 2013. Published by Elsevier Ltd.",
year = "2013",
month = "6",
day = "1",
doi = "10.1016/j.bmcl.2013.03.120",
language = "English (US)",
volume = "23",
pages = "3225--9",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - New trifluoromethyl quinolone derivatives

T2 - synthesis and investigation of antimicrobial properties

AU - Panda, Siva S

N1 - Copyright © 2013. Published by Elsevier Ltd.

PY - 2013/6/1

Y1 - 2013/6/1

N2 - A series of quinolone derivatives, containing different heterocyclic amines were prepared. Synthesized compounds were evaluated for their in vitro antimicrobial activities against two Gram-positive bacteria, three Gram-negative bacteria as well as four fungi. All the derivatives showed good activity towards Gram-positive bacteria and less activity towards Gram-negative bacteria. They also showed moderate to comparable activity against Aspergillus niger and Candida albicans and low to moderate antifungal activity against Aspergillus fumigatus and Aspergillus flavus.

AB - A series of quinolone derivatives, containing different heterocyclic amines were prepared. Synthesized compounds were evaluated for their in vitro antimicrobial activities against two Gram-positive bacteria, three Gram-negative bacteria as well as four fungi. All the derivatives showed good activity towards Gram-positive bacteria and less activity towards Gram-negative bacteria. They also showed moderate to comparable activity against Aspergillus niger and Candida albicans and low to moderate antifungal activity against Aspergillus fumigatus and Aspergillus flavus.

KW - Amines

KW - Anti-Infective Agents

KW - Aspergillus flavus

KW - Aspergillus niger

KW - Candida albicans

KW - Fluorine

KW - Gram-Negative Bacteria

KW - Gram-Positive Bacteria

KW - Microbial Sensitivity Tests

KW - Quinolones

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.bmcl.2013.03.120

DO - 10.1016/j.bmcl.2013.03.120

M3 - Article

C2 - 23611733

VL - 23

SP - 3225

EP - 3229

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 11

ER -