Niacin modulates macrophage polarization in Parkinson's disease

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation. Varied niacin dosages for longer durations may further reveal the potential role of anti-inflammatory interventions in PD progression.

Original languageEnglish (US)
Pages (from-to)76-79
Number of pages4
JournalJournal of Neuroimmunology
Volume320
DOIs
StatePublished - Jul 15 2018

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Niacin
Parkinson Disease
Macrophages
Anti-Inflammatory Agents
Disease Progression
Quality of Life
Inflammation

Keywords

  • GPR109A
  • Macrophage polarization
  • Niacin
  • Parkinson's disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

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title = "Niacin modulates macrophage polarization in Parkinson's disease",
abstract = "Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation. Varied niacin dosages for longer durations may further reveal the potential role of anti-inflammatory interventions in PD progression.",
keywords = "GPR109A, Macrophage polarization, Niacin, Parkinson's disease",
author = "Wakade, {Chandramohan G.} and Banabihari Giri and Aneeq Malik and Hesam Khodadadi and Morgan, {John Christopher} and Chong, {Kwong Yew Raymond} and Babak Baban",
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T1 - Niacin modulates macrophage polarization in Parkinson's disease

AU - Wakade, Chandramohan G.

AU - Giri, Banabihari

AU - Malik, Aneeq

AU - Khodadadi, Hesam

AU - Morgan, John Christopher

AU - Chong, Kwong Yew Raymond

AU - Baban, Babak

PY - 2018/7/15

Y1 - 2018/7/15

N2 - Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation. Varied niacin dosages for longer durations may further reveal the potential role of anti-inflammatory interventions in PD progression.

AB - Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation. Varied niacin dosages for longer durations may further reveal the potential role of anti-inflammatory interventions in PD progression.

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