Nicotinic Receptor Ligands and Novel Object Recognition

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recognition memory is one of the domains of cognition that is often impaired in neurologic and psychiatric illnesses such as Alzheimer's disease and schizophrenia. Accordingly, recognition memory is considered as an important therapeutic target in these disorders. Considerable preclinical evidence supports the argument that ligands at nicotinic acetylcholine receptors (nAChRs) may have the potential to improve several domains of cognition including recognition memory in the aforementioned neuropsychiatric disorders. The purpose of this chapter (while not all inclusive) is to provide an overview of a variety of nAChR ligands, which have been evaluated, in preclinical studies (specifically in rodents), for their effects on recognition memory in the classic (nonspatial) novel object recognition test. Due to their densities in the mammalian brain, the chapter will focus on ligands with high affinity for α4β2 nAChR and low affinity for α7 nAChR.

Original languageEnglish (US)
Title of host publicationHandbook of Behavioral Neuroscience
PublisherElsevier B.V.
Pages379-390
Number of pages12
DOIs
StatePublished - Jan 1 2018

Publication series

NameHandbook of Behavioral Neuroscience
Volume27
ISSN (Print)1569-7339

Keywords

  • Acetylcholine
  • Alzheimer's disease
  • Animal model
  • Cholinergic
  • Cognition
  • Memory
  • Preclinical
  • Schizophrenia

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

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  • Cite this

    Callahan, P. M., & Terry, A. V. (2018). Nicotinic Receptor Ligands and Novel Object Recognition. In Handbook of Behavioral Neuroscience (pp. 379-390). (Handbook of Behavioral Neuroscience; Vol. 27). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-812012-5.00026-4