Abstract
Recognition memory is one of the domains of cognition that is often impaired in neurologic and psychiatric illnesses such as Alzheimer's disease and schizophrenia. Accordingly, recognition memory is considered as an important therapeutic target in these disorders. Considerable preclinical evidence supports the argument that ligands at nicotinic acetylcholine receptors (nAChRs) may have the potential to improve several domains of cognition including recognition memory in the aforementioned neuropsychiatric disorders. The purpose of this chapter (while not all inclusive) is to provide an overview of a variety of nAChR ligands, which have been evaluated, in preclinical studies (specifically in rodents), for their effects on recognition memory in the classic (nonspatial) novel object recognition test. Due to their densities in the mammalian brain, the chapter will focus on ligands with high affinity for α4β2 nAChR and low affinity for α7 nAChR.
| Original language | English (US) |
|---|---|
| Title of host publication | Handbook of Behavioral Neuroscience |
| Publisher | Elsevier B.V. |
| Pages | 379-390 |
| Number of pages | 12 |
| DOIs | |
| State | Published - Jan 1 2018 |
Publication series
| Name | Handbook of Behavioral Neuroscience |
|---|---|
| Volume | 27 |
| ISSN (Print) | 1569-7339 |
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Keywords
- Acetylcholine
- Alzheimer's disease
- Animal model
- Cholinergic
- Cognition
- Memory
- Preclinical
- Schizophrenia
ASJC Scopus subject areas
- Cognitive Neuroscience
- Behavioral Neuroscience
Cite this
Nicotinic Receptor Ligands and Novel Object Recognition. / Callahan, Patrick Michael; Terry, Alvin V.
Handbook of Behavioral Neuroscience. Elsevier B.V., 2018. p. 379-390 (Handbook of Behavioral Neuroscience; Vol. 27).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Nicotinic Receptor Ligands and Novel Object Recognition
AU - Callahan, Patrick Michael
AU - Terry, Alvin V
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Recognition memory is one of the domains of cognition that is often impaired in neurologic and psychiatric illnesses such as Alzheimer's disease and schizophrenia. Accordingly, recognition memory is considered as an important therapeutic target in these disorders. Considerable preclinical evidence supports the argument that ligands at nicotinic acetylcholine receptors (nAChRs) may have the potential to improve several domains of cognition including recognition memory in the aforementioned neuropsychiatric disorders. The purpose of this chapter (while not all inclusive) is to provide an overview of a variety of nAChR ligands, which have been evaluated, in preclinical studies (specifically in rodents), for their effects on recognition memory in the classic (nonspatial) novel object recognition test. Due to their densities in the mammalian brain, the chapter will focus on ligands with high affinity for α4β2 nAChR and low affinity for α7 nAChR.
AB - Recognition memory is one of the domains of cognition that is often impaired in neurologic and psychiatric illnesses such as Alzheimer's disease and schizophrenia. Accordingly, recognition memory is considered as an important therapeutic target in these disorders. Considerable preclinical evidence supports the argument that ligands at nicotinic acetylcholine receptors (nAChRs) may have the potential to improve several domains of cognition including recognition memory in the aforementioned neuropsychiatric disorders. The purpose of this chapter (while not all inclusive) is to provide an overview of a variety of nAChR ligands, which have been evaluated, in preclinical studies (specifically in rodents), for their effects on recognition memory in the classic (nonspatial) novel object recognition test. Due to their densities in the mammalian brain, the chapter will focus on ligands with high affinity for α4β2 nAChR and low affinity for α7 nAChR.
KW - Acetylcholine
KW - Alzheimer's disease
KW - Animal model
KW - Cholinergic
KW - Cognition
KW - Memory
KW - Preclinical
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85056639674&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056639674&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-812012-5.00026-4
DO - 10.1016/B978-0-12-812012-5.00026-4
M3 - Chapter
AN - SCOPUS:85056639674
T3 - Handbook of Behavioral Neuroscience
SP - 379
EP - 390
BT - Handbook of Behavioral Neuroscience
PB - Elsevier B.V.
ER -