Nilotinib for the treatment of Philadelphia-chromosome-positive chronic myeloid leukemia

Amber Fullmer, Hagop Kantarjian, Jorge Cortes, Elias Jabbour

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Importance of the field: Although the introduction of imatinib revolutionized the management of chronic myeloid leukemia (CML), some patients exhibit resistance or intolerance to the drug. Nilotinib induces high and rapid rates of cytogenetic and molecular responses. With recent approval for newly diagnosed patients with chronic phase CML, the current algorithm for treatment will probably be transformed. Areas covered in this review: This review will describe evaluations of nilotinib in all phases of CML from 1995 to the present. Early preclinical data and Phase I, Phase II and Phase III evaluations will demonstrate the role of nilotinib in newly diagnosed CML, as well as in imatinib-resistant or imatinib-intolerant disease. What the reader will gain: Mutations in the BCR-ABL kinase domain are responsible for the majority of resistance to imatinib. In comparison with imatinib, nilotinib displays increased selectivity and potency at inhibiting proliferation of BCR-ABL expressing cells. Although several mutations, including T315I, remain resistant to nilotinib, activity in all phases of CML has been reported. Take home message: Nilotinib induces high and rapid rates of cytogenetic and molecular response, with less progression to advanced forms of disease compared with imatinib. Considering that the rapid achievement of these clinical milestones has been associated with positive long-term outcomes, nilotinib as initial therapy in patients with CML in chronic phase represents the future in CML treatment. Longer follow-up is necessary to recognize survival advantages.

Original languageEnglish (US)
Pages (from-to)3065-3072
Number of pages8
JournalExpert Opinion on Pharmacotherapy
Volume11
Issue number18
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Keywords

  • Chronic myeloid leukemia
  • Nilotinib
  • Tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Nilotinib for the treatment of Philadelphia-chromosome-positive chronic myeloid leukemia'. Together they form a unique fingerprint.

Cite this