Nitric oxide diminishes pulmonary hypertension without affecting capillary surface area

Lyle E Fisher, C. Steinhart, J. D. Catravas

Research output: Contribution to journalArticle

Abstract

We hypothesized that pulmonary capillary recruitment does not depend solely on extracapillary factors. We investigated the effects of inhaled nitric oxide (NO) on segmental pulmonary resistances and dynamically perfused capillary surface area (DPCSA) in rabbits (n=9) placed on cardiac bypass Pulmonary and sytemic arterial and left atrial pressures were continuously monitored. Vascular occlusion techniques were used to determine pulmonary segmental pressures. DPCSA was determined from the transpulmonary metabolism of [3H]-Benzoyl-Phe-Ala-Pro. The pulmonary circulation was constricted by serotonin, then relaxed using increasing concentrations of NO (N01, NO2). Fold-increases from baseline, ±s e.ni Resistance Constricted NO1 NO2 Total 1.55 ±0.10 .27 ±0.08 1.00 ±0.040 Artery 1.53 ±0.10 .35 ±0.19 0 96 ±0.10-Mf Arteriole 2.49 ±0.50 .96 ±0.40 1.06 ±0.301 Venule 1.34 ±0.40 .13 ±0.29 1.23 ±0.21 Vein 1.51 ±0.28 .36 ±0.44 1.23 ±0.20 DPCSA 0.99 ±0.10 0.79 ±0.11 0.88 ±0.08 from Baseline,+ from Constricted, # from N01, by ANOVA p<0.05 NO reduced pulmonary arterial and pulmonary arteriolar resistances without affecting capillary surface area. This supports our hypothesis and suggests that tllf+. r.anillarv hf»H mau ftrtivplv mnHnlatp itc own iwmitmdnt.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - Dec 1 1996

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Pulmonary Hypertension
hypertension
nitric oxide
surface area
Nitric Oxide
lungs
Lung
nitrogen dioxide
phenylalanylalanine
Analysis of variance (ANOVA)
Metabolism
Serotonin
Pulmonary Circulation
Atrial Pressure
Venules
Arterioles
Blood Vessels
Veins
blood vessels
serotonin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Nitric oxide diminishes pulmonary hypertension without affecting capillary surface area. / Fisher, Lyle E; Steinhart, C.; Catravas, J. D.

In: FASEB Journal, Vol. 10, No. 3, 01.12.1996.

Research output: Contribution to journalArticle

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