NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation

E. Shimizu, Y. P. Tang, C. Rampon, Joseph Zhuo Tsien

Research output: Contribution to journalArticle

432 Citations (Scopus)

Abstract

The hippocampal CA1 region is crucial for converting new memories into long-term memories, a process believed to continue for week(s) after initial learning. By developing an inducible, reversible, and CA1-specific knockout technique, we could switch N-methyl-D-aspartate (NMDA) receptor function off or on in CA1 during the consolidation period. Our data indicate that memory consolidation depends on the reactivation of the NMDA receptor, possibly to reinforce site-specific synaptic modifications to consolidate memory traces. Such a synaptic reinforcement process may also serve as a cellular means by which the new memory is transferred from the hippocampus to the cortex for permanent storage.

Original languageEnglish (US)
Pages (from-to)1170-1174
Number of pages5
JournalScience
Volume290
Issue number5494
DOIs
StatePublished - Nov 10 2000
Externally publishedYes

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N-Methyl-D-Aspartate Receptors
Hippocampal CA1 Region
Long-Term Memory
Hippocampus
Learning
Reinforcement (Psychology)
Memory Consolidation

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. / Shimizu, E.; Tang, Y. P.; Rampon, C.; Tsien, Joseph Zhuo.

In: Science, Vol. 290, No. 5494, 10.11.2000, p. 1170-1174.

Research output: Contribution to journalArticle

Shimizu, E. ; Tang, Y. P. ; Rampon, C. ; Tsien, Joseph Zhuo. / NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. In: Science. 2000 ; Vol. 290, No. 5494. pp. 1170-1174.
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