No primary association between the 308 polymorphism in the tumor necrosis factor α promoter region and insulin-dependent diabetes mellitus

Glenn Y. Deng, Noel K. Maclaren, Hong So Huang, Li Ping Zhang, Jin Xiong She

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43 Scopus citations


Whereas TNF-α has been implicated in the pathogenesis of IDDM, its possible role as a primary genetic susceptibility factor has not been well investigated. In this study, we analyzed a biallelic polymorphism in the TNF- α promotor region in a large collection of IDDM patients and controls ascertained from two ethnic populations (U.S. Caucasians and Chinese in Taiwan). We report that the associations with TNF-α are due to linkage disequilibrium between TNF-α and the DR3-DQB1*0201 haplotype in both ethnic populations. Our analyses of extended haplotypes for the HLA region further substantiate the conclusion that no primary association exists between IDDM and the TNF-α promoter polymorphism.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalHuman Immunology
Issue number2
StatePublished - Feb 1996
Externally publishedYes


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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