No primary association between the 308 polymorphism in the tumor necrosis factor α promoter region and insulin-dependent diabetes mellitus

Glenn Y. Deng, Noel K. Maclaren, Hong So Huang, Li Ping Zhang, Jin-Xiong She

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Whereas TNF-α has been implicated in the pathogenesis of IDDM, its possible role as a primary genetic susceptibility factor has not been well investigated. In this study, we analyzed a biallelic polymorphism in the TNF- α promotor region in a large collection of IDDM patients and controls ascertained from two ethnic populations (U.S. Caucasians and Chinese in Taiwan). We report that the associations with TNF-α are due to linkage disequilibrium between TNF-α and the DR3-DQB1*0201 haplotype in both ethnic populations. Our analyses of extended haplotypes for the HLA region further substantiate the conclusion that no primary association exists between IDDM and the TNF-α promoter polymorphism.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalHuman Immunology
Volume45
Issue number2
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

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Type 1 Diabetes Mellitus
Genetic Promoter Regions
Tumor Necrosis Factor-alpha
Haplotypes
Linkage Disequilibrium
Genetic Predisposition to Disease
Taiwan
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

No primary association between the 308 polymorphism in the tumor necrosis factor α promoter region and insulin-dependent diabetes mellitus. / Deng, Glenn Y.; Maclaren, Noel K.; Huang, Hong So; Zhang, Li Ping; She, Jin-Xiong.

In: Human Immunology, Vol. 45, No. 2, 01.01.1996, p. 137-142.

Research output: Contribution to journalArticle

Deng, Glenn Y. ; Maclaren, Noel K. ; Huang, Hong So ; Zhang, Li Ping ; She, Jin-Xiong. / No primary association between the 308 polymorphism in the tumor necrosis factor α promoter region and insulin-dependent diabetes mellitus. In: Human Immunology. 1996 ; Vol. 45, No. 2. pp. 137-142.
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