Abstract
Nogo-B is a known regulator of neural functions and plays an important role in cell adhesion and migration. To our knowledge, the molecular mechanism behind its regulation of cell motility is still unknown. Here, we identified Fibulin-5, a secreted extracellular matrix protein, as a binding partner of Nogo-B. Using HeLa cells as a model, we found that Nogo-B and Fibulin-5 co-localize in the cytoplasm and plasma membrane. Furthermore, in HeLa cells that overexpress Nogo-B, cell migration and invasion was promoted by the elevated secretion of Fibulin-5. Thus, identification of the Nogo-B binding protein Fibulin-5 may contribute to uncover the pathway in which Nogo-B regulates tumor cell movement.
Original language | English (US) |
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Pages (from-to) | 247-253 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 398 |
Issue number | 2 |
DOIs | |
State | Published - Jul 2010 |
Keywords
- Cell motility
- Fibulin-5
- Nogo-B
- Secretion
- Tumor metastasis
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology