Non-Hodgkin's lymphoma presenting as anasarca: Probably mediated by tumor necrosis factor alpha (TNF-α)

Anand Jillella, D. Scott Day, Kathirae Severson, Andre M. Kallab, Russell Burgess

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Two patients presented with anasarca, fevers and sweats. Subsequent evaluation revealed aggressive lymphoproliferative disease. Both patients were treated with CHOP chemotherapy. One patient responded with spontaneous, vigorous diuresis and complete resolution of the edema. She relapsed two months later with recurrent edema that responded a second time to salvage chemotherapy. The second patient died of gram positive sepsis a week after diagnosis. As anasarca is an unusual presenting symptom of non-Hodgkin's lymphoma, we postulated that the malignant cells were secreting a cytokine that resulted in 'vascular leakage' of fluid and development of diffuse edema. Several serum cytokine levels were tested. Both patients had elevated TNF-α levels, which could have been the cause of the edema; or there might be yet another unidentified mediator that was responsible for the anasarca. We report these two cases to bring to attention the unusual nature of this presentation.

Original languageEnglish (US)
Pages (from-to)419-422
Number of pages4
JournalLeukemia and Lymphoma
Volume38
Issue number3-4
DOIs
StatePublished - Jan 1 2000

Fingerprint

Non-Hodgkin's Lymphoma
Edema
Tumor Necrosis Factor-alpha
Cytokines
Drug Therapy
Sweat
Diuresis
Blood Vessels
Sepsis
Fever
Serum

Keywords

  • Anasarea
  • Edema
  • Non-Hodgkin's lymphoma
  • TNF-α

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Non-Hodgkin's lymphoma presenting as anasarca : Probably mediated by tumor necrosis factor alpha (TNF-α). / Jillella, Anand; Day, D. Scott; Severson, Kathirae; Kallab, Andre M.; Burgess, Russell.

In: Leukemia and Lymphoma, Vol. 38, No. 3-4, 01.01.2000, p. 419-422.

Research output: Contribution to journalArticle

Jillella, Anand ; Day, D. Scott ; Severson, Kathirae ; Kallab, Andre M. ; Burgess, Russell. / Non-Hodgkin's lymphoma presenting as anasarca : Probably mediated by tumor necrosis factor alpha (TNF-α). In: Leukemia and Lymphoma. 2000 ; Vol. 38, No. 3-4. pp. 419-422.
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