Non-spherical nanostructures in nanomedicine: From noble metal nanorods to transition metal dichalcogenide nanosheets

Pooyan Makvandi, Atefeh Zarepour, Xuanqi Zheng, Tarun Agarwal, Matineh Ghomi, Rossella Sartorius, Ehsan Nazarzadeh Zare, Ali Zarrabi, Aimin Wu, Tapas Kumar Maiti, Bryan Ronain Smith, Rajender S. Varma, Franklin R. Tay, Virgilio Mattoli

Research output: Contribution to journalReview articlepeer-review

Abstract

Non-spherical metal nanomaterials such as noble metal or transition metal dichalcogenides and MXenes have been employed in different biomedical facets. Because the biological properties of these nanocompounds are governed by their architecture and composition, such factors should be considered prior to their adoption for clinical use. The architecture of metal-based nanomaterials affects cell viability by virtue of the variable geometry of these nanomaterials as well as their physicochemical interactions with mammalian cell membranes. In the present review, the effects of parameters such as interfacial interaction and aspect ratio on cellular uptake of non-spherical metallic nanomaterials will be discussed. The application of these nanomaterials as biosensors, in cancer diagnosis and therapy, tissue engineering and regenerative medicine will also be thoroughly reviewed.

Original languageEnglish (US)
Article number101107
JournalApplied Materials Today
Volume24
DOIs
StatePublished - Sep 2021

Keywords

  • Anti-cancer therapy
  • Cancer diagnosis
  • Endocytosis mechanism
  • MXene
  • Tissue engineering
  • Transition metal dichalcogenides

ASJC Scopus subject areas

  • Materials Science(all)

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