Noninvasive evaluation of microscopic tumor extensions using standardized uptake value and metabolic tumor volume in non-small-cell lung cancer

Xue Meng, Xindong Sun, Dianbin Mu, Ligang Xing, Li Ma, Baijiang Zhang, Shuqiang Zhao, Guoren Yang, Feng Ming Kong, Jinming Yu

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Purpose: To prospectively evaluate whether maximal microscopic extensions (MEmax) correlate with maximal standardized uptake value (SUVmax) and metabolic tumor volume (MTV) at 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) images in non-small-cell lung cancer (NSCLC). Methods and Materials: Thirty-nine patients with Stage I-IIIA NSCLC underwent surgery after FDG-PET/CT scanning. SUVmax and MTV were calculated on the PET/CT images. The maximum linear distance from the tumor margin to the farthest extent of the tumor in every dimension was measured at the tumor section. The correlations among MEmax, SUVmax, MTV and other clinical pathologic parameters were analyzed. Results: MEmax for all patients had a significant correlation with SUVmax (r = 0.777, p = 0.008) and MTV (r = 0.724, p < 0.001). When expressed in terms of the probability of covering ME with respect to a given margin, we suggested that margins of 1.93 mm, 3.90 mm, and 9.60 mm for SUVmax ≤5, 5-10, and >10 added to the gross tumor volume would be adequate to cover 95% of ME. Conclusions: This study demonstrated that tumors with high SUVmax and MTV have more MEmax and would therefore require more margin expansion from gross tumor volume to clinical target volume. FDG-PET/CT, especially for SUVmax, is promising and effective and merits additional study in noninvasive delimiting of the clinical target volume margin for NSCLC.

Original languageEnglish (US)
Pages (from-to)960-966
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume82
Issue number2
DOIs
StatePublished - Feb 1 2012

Fingerprint

Tumor Burden
Non-Small Cell Lung Carcinoma
lungs
tumors
cancer
evaluation
tomography
Neoplasms
positrons
margins
Fluorodeoxyglucose F18
surgery
Positron Emission Tomography Computed Tomography
expansion
scanning

Keywords

  • Clinical target volume margin
  • Metabolic tumor volume
  • Non-small-cell lung cancer
  • Positron emission tomography/computed tomography
  • Standardized uptake value

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Noninvasive evaluation of microscopic tumor extensions using standardized uptake value and metabolic tumor volume in non-small-cell lung cancer. / Meng, Xue; Sun, Xindong; Mu, Dianbin; Xing, Ligang; Ma, Li; Zhang, Baijiang; Zhao, Shuqiang; Yang, Guoren; Kong, Feng Ming; Yu, Jinming.

In: International Journal of Radiation Oncology Biology Physics, Vol. 82, No. 2, 01.02.2012, p. 960-966.

Research output: Contribution to journalArticle

Meng, Xue ; Sun, Xindong ; Mu, Dianbin ; Xing, Ligang ; Ma, Li ; Zhang, Baijiang ; Zhao, Shuqiang ; Yang, Guoren ; Kong, Feng Ming ; Yu, Jinming. / Noninvasive evaluation of microscopic tumor extensions using standardized uptake value and metabolic tumor volume in non-small-cell lung cancer. In: International Journal of Radiation Oncology Biology Physics. 2012 ; Vol. 82, No. 2. pp. 960-966.
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AU - Ma, Li

AU - Zhang, Baijiang

AU - Zhao, Shuqiang

AU - Yang, Guoren

AU - Kong, Feng Ming

AU - Yu, Jinming

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