Nonlinear Relationship between Birth Weight and Visceral Fat in Adolescents

Brian Kevin Stansfield, Mary Ellen Fain, Jatinder J Bhatia, Bernard Gutin, Joshua T. Nguyen, Norman K. Pollock

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective To determine the association of birth weight with abdominal fat distribution and markers known to increase risk for cardiovascular disease and type 2 diabetes in adolescents. Study design In 575 adolescents aged 14-18 years (52% female, 46% black), birth weight was obtained by parental recall. Fasting blood samples were measured for glucose, insulin, lipids, adiponectin, leptin, and C-reactive protein. Subcutaneous abdominal adipose tissue and visceral adipose tissue were assessed by magnetic resonance imaging. Results When we compared markers of cardiometabolic risk across tertiles of birth weight, adjusting for age, sex, race, Tanner stage, physical activity, socioeconomic status, and body mass index, there were significant U-shaped trends for homeostasis model assessment of insulin resistance, leptin, and visceral adipose tissue (all P quadratic <.05). A significant linear downward trend across tertiles of birth weight was observed for triglycerides (P linear =.03). There were no differences in fasting glucose, blood pressure, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, adiponectin, C-reactive protein, or subcutaneous abdominal adipose tissue across tertiles of birth weight. Conclusions Our data suggest that both low and high birth weights are associated with greater visceral adiposity and biomarkers implicated in insulin resistance and inflammation in adolescents.

Original languageEnglish (US)
Pages (from-to)185-192
Number of pages8
JournalJournal of Pediatrics
Volume174
DOIs
StatePublished - Jul 1 2016

Fingerprint

Intra-Abdominal Fat
Birth Weight
Abdominal Subcutaneous Fat
Adiponectin
Leptin
C-Reactive Protein
Insulin Resistance
Fasting
Glucose
Abdominal Fat
Adiposity
Low Birth Weight Infant
Social Class
LDL Cholesterol
Type 2 Diabetes Mellitus
HDL Cholesterol
Triglycerides
Body Mass Index
Homeostasis
Cardiovascular Diseases

Keywords

  • fetal origins
  • insulin resistance
  • metabolic syndrome
  • obesity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Nonlinear Relationship between Birth Weight and Visceral Fat in Adolescents. / Stansfield, Brian Kevin; Fain, Mary Ellen; Bhatia, Jatinder J; Gutin, Bernard; Nguyen, Joshua T.; Pollock, Norman K.

In: Journal of Pediatrics, Vol. 174, 01.07.2016, p. 185-192.

Research output: Contribution to journalArticle

@article{017fbe1350854d708d8a9cf2608c4e50,
title = "Nonlinear Relationship between Birth Weight and Visceral Fat in Adolescents",
abstract = "Objective To determine the association of birth weight with abdominal fat distribution and markers known to increase risk for cardiovascular disease and type 2 diabetes in adolescents. Study design In 575 adolescents aged 14-18 years (52{\%} female, 46{\%} black), birth weight was obtained by parental recall. Fasting blood samples were measured for glucose, insulin, lipids, adiponectin, leptin, and C-reactive protein. Subcutaneous abdominal adipose tissue and visceral adipose tissue were assessed by magnetic resonance imaging. Results When we compared markers of cardiometabolic risk across tertiles of birth weight, adjusting for age, sex, race, Tanner stage, physical activity, socioeconomic status, and body mass index, there were significant U-shaped trends for homeostasis model assessment of insulin resistance, leptin, and visceral adipose tissue (all P quadratic <.05). A significant linear downward trend across tertiles of birth weight was observed for triglycerides (P linear =.03). There were no differences in fasting glucose, blood pressure, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, adiponectin, C-reactive protein, or subcutaneous abdominal adipose tissue across tertiles of birth weight. Conclusions Our data suggest that both low and high birth weights are associated with greater visceral adiposity and biomarkers implicated in insulin resistance and inflammation in adolescents.",
keywords = "fetal origins, insulin resistance, metabolic syndrome, obesity",
author = "Stansfield, {Brian Kevin} and Fain, {Mary Ellen} and Bhatia, {Jatinder J} and Bernard Gutin and Nguyen, {Joshua T.} and Pollock, {Norman K.}",
year = "2016",
month = "7",
day = "1",
doi = "10.1016/j.jpeds.2016.04.012",
language = "English (US)",
volume = "174",
pages = "185--192",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",

}

TY - JOUR

T1 - Nonlinear Relationship between Birth Weight and Visceral Fat in Adolescents

AU - Stansfield, Brian Kevin

AU - Fain, Mary Ellen

AU - Bhatia, Jatinder J

AU - Gutin, Bernard

AU - Nguyen, Joshua T.

AU - Pollock, Norman K.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Objective To determine the association of birth weight with abdominal fat distribution and markers known to increase risk for cardiovascular disease and type 2 diabetes in adolescents. Study design In 575 adolescents aged 14-18 years (52% female, 46% black), birth weight was obtained by parental recall. Fasting blood samples were measured for glucose, insulin, lipids, adiponectin, leptin, and C-reactive protein. Subcutaneous abdominal adipose tissue and visceral adipose tissue were assessed by magnetic resonance imaging. Results When we compared markers of cardiometabolic risk across tertiles of birth weight, adjusting for age, sex, race, Tanner stage, physical activity, socioeconomic status, and body mass index, there were significant U-shaped trends for homeostasis model assessment of insulin resistance, leptin, and visceral adipose tissue (all P quadratic <.05). A significant linear downward trend across tertiles of birth weight was observed for triglycerides (P linear =.03). There were no differences in fasting glucose, blood pressure, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, adiponectin, C-reactive protein, or subcutaneous abdominal adipose tissue across tertiles of birth weight. Conclusions Our data suggest that both low and high birth weights are associated with greater visceral adiposity and biomarkers implicated in insulin resistance and inflammation in adolescents.

AB - Objective To determine the association of birth weight with abdominal fat distribution and markers known to increase risk for cardiovascular disease and type 2 diabetes in adolescents. Study design In 575 adolescents aged 14-18 years (52% female, 46% black), birth weight was obtained by parental recall. Fasting blood samples were measured for glucose, insulin, lipids, adiponectin, leptin, and C-reactive protein. Subcutaneous abdominal adipose tissue and visceral adipose tissue were assessed by magnetic resonance imaging. Results When we compared markers of cardiometabolic risk across tertiles of birth weight, adjusting for age, sex, race, Tanner stage, physical activity, socioeconomic status, and body mass index, there were significant U-shaped trends for homeostasis model assessment of insulin resistance, leptin, and visceral adipose tissue (all P quadratic <.05). A significant linear downward trend across tertiles of birth weight was observed for triglycerides (P linear =.03). There were no differences in fasting glucose, blood pressure, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, adiponectin, C-reactive protein, or subcutaneous abdominal adipose tissue across tertiles of birth weight. Conclusions Our data suggest that both low and high birth weights are associated with greater visceral adiposity and biomarkers implicated in insulin resistance and inflammation in adolescents.

KW - fetal origins

KW - insulin resistance

KW - metabolic syndrome

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=84965095687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84965095687&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2016.04.012

DO - 10.1016/j.jpeds.2016.04.012

M3 - Article

VL - 174

SP - 185

EP - 192

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -