Nonmotor manifestations of Parkinson's disease

Tanya Simuni, Kapil Dev Sethi

Research output: Contribution to journalReview article

154 Citations (Scopus)

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Traditionally, attention has focused on the motor symptomatology of PD, but it is now appreciated that the nonmotor symptoms affecting neuropsychiatric, sleep, autonomic, and sensory domains occur in up to 88% of PD patients and can be an important source of disability. Nonmotor manifestations of PD play a significant role in the impairment of disease-related quality of life. The cause of nonmotor manifestations of PD is multifactorial, but to a large extent, these manifestations are related to the nature of the neurodegenerative process and the widespread nondopaminergic neuropathological changes associated with the disease. Recognition of nonmotor disability is essential not only for ascertaining the functional status of patients but also for better appreciating the nature of the neurodegenerative process in PD. In addition, a number of nonmotor manifestations can precede the onset of motor symptoms in PD and can be used as screening tools allowing for early disease identification and for trials of possible disease-modifying interventions. This article reviews depression, sleep, and autonomic dysfunction in PD.

Original languageEnglish (US)
JournalAnnals of Neurology
Volume64
Issue numberSUPPL. 2
DOIs
StatePublished - Dec 1 2008

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Parkinson Disease
Sleep
Neurodegenerative Diseases
Alzheimer Disease
Quality of Life
Depression

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Nonmotor manifestations of Parkinson's disease. / Simuni, Tanya; Sethi, Kapil Dev.

In: Annals of Neurology, Vol. 64, No. SUPPL. 2, 01.12.2008.

Research output: Contribution to journalReview article

Simuni, Tanya ; Sethi, Kapil Dev. / Nonmotor manifestations of Parkinson's disease. In: Annals of Neurology. 2008 ; Vol. 64, No. SUPPL. 2.
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