Nonviral vector gene modification of stem cells for myocardial repair

Husnain K. Haider, Ibrahim Elmadbouh, Michel Jean-Baptiste, Muhammad Ashraf

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Therapeutic angiogenesis and myogenesis restore perfusion of ischemic myocardium and improve left ventricular contractility. These therapeutic modalities must be considered as complementary rather than competing to exploit their advantages for optimal beneficial effects. The resistant nature of cardiomyocytes to gene transfection can be overcome by ex vivo delivery of therapeutic genes to the heart using genetically modified stem cells. This review article gives an overview of different vectors and delivery systems in general used for therapeutic gene delivery to the heart and provides a critical appreciation of the ex vivo gene delivery approach using genetically modified stem cells to achieve angiomyogenesis for the treatment of infarcted heart.

Original languageEnglish (US)
Pages (from-to)79-86
Number of pages8
JournalMolecular Medicine
Volume14
Issue number1-2
DOIs
StatePublished - Jan 2008

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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