Nos induction by ngf in basal forebrain cholinergic neurones

Evidence for regulation of brain nos by a neurotrophin

David M. Holtzman, Joshua Kilbridge, David S. Bredt, Stephen Matthew Black, Yiwen Li, Douglas O. Clary, Louis F. Reichardt, William C. Mobley

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Nerve growth factor (NGF) acts through trkA receptors to serve as a trophic factor for cholinergic neurones in the medial septal nucleus (MSN) and vertical Limb of the diagonal band (VDB). Herein, we show that brain nitric oxide synthase (NOS), which synthesizes the neuromodulator nitric oxide, is selectively expressed in a large fraction of trkA-containing neurones in the MSN and VDB. Axotomy of these neurones gave evidence that NOS expressing cholinergic neurones innervate the hippocampus. NGF infusion induced a robust, specific increase in NOS expression in basal forebrain cholinergic neurones. These results indicate that brain NOS can be regulated by a neurotrophic factor and suggest that NGF influences forebrain function by regulating production of nitric oxide as well as acetylcholine.

Original languageEnglish (US)
Pages (from-to)51-60
Number of pages10
JournalNeurobiology of Disease
Volume1
Issue number1-2
DOIs
StatePublished - Jan 1 1994

Fingerprint

Cholinergic Neurons
Nerve Growth Factors
Nitric Oxide Synthase
Nerve Growth Factor
Septal Nuclei
Brain
Nitric Oxide
Extremities
trkA Receptor
Neurons
Axotomy
Prosencephalon
Acetylcholine
Neurotransmitter Agents
Hippocampus
Basal Forebrain

Keywords

  • Glycollate
  • Nerve growth factor
  • Neurotrophic factor
  • Neurotrophin
  • Nitric oxide synthase
  • Sodium pentosan polysulphate

ASJC Scopus subject areas

  • Neurology

Cite this

Holtzman, D. M., Kilbridge, J., Bredt, D. S., Black, S. M., Li, Y., Clary, D. O., ... Mobley, W. C. (1994). Nos induction by ngf in basal forebrain cholinergic neurones: Evidence for regulation of brain nos by a neurotrophin. Neurobiology of Disease, 1(1-2), 51-60. https://doi.org/10.1006/nbdi.1994.0007

Nos induction by ngf in basal forebrain cholinergic neurones : Evidence for regulation of brain nos by a neurotrophin. / Holtzman, David M.; Kilbridge, Joshua; Bredt, David S.; Black, Stephen Matthew; Li, Yiwen; Clary, Douglas O.; Reichardt, Louis F.; Mobley, William C.

In: Neurobiology of Disease, Vol. 1, No. 1-2, 01.01.1994, p. 51-60.

Research output: Contribution to journalArticle

Holtzman, DM, Kilbridge, J, Bredt, DS, Black, SM, Li, Y, Clary, DO, Reichardt, LF & Mobley, WC 1994, 'Nos induction by ngf in basal forebrain cholinergic neurones: Evidence for regulation of brain nos by a neurotrophin', Neurobiology of Disease, vol. 1, no. 1-2, pp. 51-60. https://doi.org/10.1006/nbdi.1994.0007
Holtzman, David M. ; Kilbridge, Joshua ; Bredt, David S. ; Black, Stephen Matthew ; Li, Yiwen ; Clary, Douglas O. ; Reichardt, Louis F. ; Mobley, William C. / Nos induction by ngf in basal forebrain cholinergic neurones : Evidence for regulation of brain nos by a neurotrophin. In: Neurobiology of Disease. 1994 ; Vol. 1, No. 1-2. pp. 51-60.
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