Novel adaptive and innate immunity targets in hypertension

Justine M. Abais-Battad, John Henry Dasinger, Daniel J. Fehrenbach, David L. Mattson

Research output: Contribution to journalReview article

Abstract

Hypertension is a worldwide epidemic and global health concern as it is a major risk factor for the development of cardiovascular diseases. A relationship between the immune system and its contributing role to the pathogenesis of hypertension has been long established, but substantial advancements within the last few years have dissected specific causal molecular mechanisms. This review will briefly examine these recent studies exploring the involvement of either innate or adaptive immunity pathways. Such pathways to be discussed include innate immunity factors such as antigen presenting cells and pattern recognition receptors, adaptive immune elements including T and B lymphocytes, and more specifically, the emerging role of T regulatory cells, as well as the potential of cytokines and chemokines to serve as signaling messengers connecting innate and adaptive immunity. Together, we summarize these studies to provide new perspective for what will hopefully lead to more targeted approaches to manipulate the immune system as hypertensive therapy.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalPharmacological Research
Volume120
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Fingerprint

Adaptive Immunity
Innate Immunity
Hypertension
Immune System
Pattern Recognition Receptors
Antigen-Presenting Cells
Regulatory T-Lymphocytes
Chemokines
B-Lymphocytes
Cardiovascular Diseases
Cytokines
T-Lymphocytes
Global Health
Therapeutics

Keywords

  • Adaptive immunity
  • Antigen presenting cells
  • Hypertension
  • Innate immunity
  • Lymphocytes

ASJC Scopus subject areas

  • Pharmacology

Cite this

Abais-Battad, J. M., Dasinger, J. H., Fehrenbach, D. J., & Mattson, D. L. (2017). Novel adaptive and innate immunity targets in hypertension. Pharmacological Research, 120, 109-115. https://doi.org/10.1016/j.phrs.2017.03.015

Novel adaptive and innate immunity targets in hypertension. / Abais-Battad, Justine M.; Dasinger, John Henry; Fehrenbach, Daniel J.; Mattson, David L.

In: Pharmacological Research, Vol. 120, 01.06.2017, p. 109-115.

Research output: Contribution to journalReview article

Abais-Battad, JM, Dasinger, JH, Fehrenbach, DJ & Mattson, DL 2017, 'Novel adaptive and innate immunity targets in hypertension', Pharmacological Research, vol. 120, pp. 109-115. https://doi.org/10.1016/j.phrs.2017.03.015
Abais-Battad JM, Dasinger JH, Fehrenbach DJ, Mattson DL. Novel adaptive and innate immunity targets in hypertension. Pharmacological Research. 2017 Jun 1;120:109-115. https://doi.org/10.1016/j.phrs.2017.03.015
Abais-Battad, Justine M. ; Dasinger, John Henry ; Fehrenbach, Daniel J. ; Mattson, David L. / Novel adaptive and innate immunity targets in hypertension. In: Pharmacological Research. 2017 ; Vol. 120. pp. 109-115.
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