Novel antibacterial active quinolone-fluoroquinolone conjugates and 2D-QSAR studies

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Abstract

Novel, quinolone-fluoroquinolone conjugates 10a-f, 11a-f, 13a-f and 14a-f with amino acid linkers were synthesized in good yields utilizing benzotriazole chemistry. Antibacterial bioassay showed the synthesized bis-conjugates exhibit anti-bacterial properties comparable with the parent drugs.

Original languageEnglish (US)
Pages (from-to)3816-21
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number18
DOIs
StatePublished - Sep 15 2015

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Keywords

  • Anti-Bacterial Agents
  • Dose-Response Relationship, Drug
  • Gram-Negative Bacteria
  • Gram-Positive Bacteria
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Quantitative Structure-Activity Relationship
  • Quinolones
  • Journal Article
  • Research Support, Non-U.S. Gov't

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