Abstract
Novel, quinolone-fluoroquinolone conjugates 10a-f, 11a-f, 13a-f and 14a-f with amino acid linkers were synthesized in good yields utilizing benzotriazole chemistry. Antibacterial bioassay showed the synthesized bis-conjugates exhibit anti-bacterial properties comparable with the parent drugs.
Original language | English (US) |
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Pages (from-to) | 3816-21 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 25 |
Issue number | 18 |
DOIs | |
State | Published - Sep 15 2015 |
Keywords
- Anti-Bacterial Agents
- Dose-Response Relationship, Drug
- Gram-Negative Bacteria
- Gram-Positive Bacteria
- Microbial Sensitivity Tests
- Molecular Structure
- Quantitative Structure-Activity Relationship
- Quinolones
- Journal Article
- Research Support, Non-U.S. Gov't