Novel antimicrobial peptides that exhibit activity against select agents and other drug resistant bacteria

Divakaramenon Venugopal, David Klapper, Antoine H. Srouji, Jayendra B. Bhonsle, Richard Borschel, Allen Mueller, Amanda L. Russell, Brittany C. Williams, Rickey P. Hicks

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

One of the greatest challenges facing modern medicine is the evolution of drug resistant strains of bacteria. In addition to traditional methods of exposure to traditional bacterial organisms there is a growing concerned of the use of bacteria as bio-terrorism agents. To counter the evolution of drug resistant and potential bio-terrorism bacterial agents new antibiotic drugs must be developed. One potential source of new therapeutic agents that act via a novel mechanism of action are natural and synthetic antimicrobial peptides (AMPs). In our laboratories we have developed a series of AMPs incorporating the un-natural amino acids Tic-Oic to impart organism selectivity and potency while increasing metabolic stability. Herein the in vitro activity of these peptides, including ten new compounds, against eight potential bio-terrorism bacterial agents and three other bacterial strains is presented and discussed. These peptides exhibit a wide range of organism potency and selectivity. Calcein fluorescence leakage and circular dichroism studies were conducted to confirm that these peptides interact with zwitterionic and anionic liposomes.

Original languageEnglish (US)
Pages (from-to)5137-5147
Number of pages11
JournalBioorganic and Medicinal Chemistry
Volume18
Issue number14
DOIs
StatePublished - Jul 15 2010

Keywords

  • Antimicrobial peptides
  • In vitro activity
  • MRSA
  • Select bacterial agents

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Venugopal, D., Klapper, D., Srouji, A. H., Bhonsle, J. B., Borschel, R., Mueller, A., Russell, A. L., Williams, B. C., & Hicks, R. P. (2010). Novel antimicrobial peptides that exhibit activity against select agents and other drug resistant bacteria. Bioorganic and Medicinal Chemistry, 18(14), 5137-5147. https://doi.org/10.1016/j.bmc.2010.05.065