Novel Biomedical Applications of Crosslinked Collagen

Lisha Gu, Tiantian Shan, Yu xuan Ma, Franklin Chi Meng Tay, Lina Niu

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Collagen is one of the most useful biopolymers because of its low immunogenicity and biocompatibility. The biomedical potential of natural collagen is limited by its poor mechanical strength, thermal stability, and enzyme resistance, but exogenous chemical, physical, or biological crosslinks have been used to modify the molecular structure of collagen to minimize degradation and enhance mechanical stability. Although crosslinked collagen-based materials have been widely used in biomedicine, there is no standard crosslinking protocol that can achieve a perfect balance between stability and functional remodeling of collagen. Understanding the role of crosslinking agents in the modification of collagen performance and their potential biomedical applications are crucial for developing novel collagen-based biopolymers for therapeutic gain.

Original languageEnglish (US)
Pages (from-to)464-491
Number of pages28
JournalTrends in Biotechnology
Volume37
Issue number5
DOIs
StatePublished - May 1 2019

Fingerprint

Collagen
Biopolymers
Crosslinking
Enzyme Stability
Mechanical stability
Molecular Structure
Biocompatibility
Molecular structure
Strength of materials
Thermodynamic stability
Enzymes
Hot Temperature
Degradation

Keywords

  • collagen
  • crosslink
  • stability
  • tissue engineering
  • tissue repair

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

Cite this

Novel Biomedical Applications of Crosslinked Collagen. / Gu, Lisha; Shan, Tiantian; Ma, Yu xuan; Tay, Franklin Chi Meng; Niu, Lina.

In: Trends in Biotechnology, Vol. 37, No. 5, 01.05.2019, p. 464-491.

Research output: Contribution to journalReview article

Gu, Lisha ; Shan, Tiantian ; Ma, Yu xuan ; Tay, Franklin Chi Meng ; Niu, Lina. / Novel Biomedical Applications of Crosslinked Collagen. In: Trends in Biotechnology. 2019 ; Vol. 37, No. 5. pp. 464-491.
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