Novel insights into TRPV4 function in the kidney

Oleh Pochynyuk, Oleg Zaika, Roger G. O'Neil, Mykola Mamenko

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Kidneys are complex highly organized paired organs of nearly one million nephrons each. They rigorously process about 180 l of plasma daily to keep whole body homeostasis. To effectively perform such a titanic work, kidneys rely on mechanisms able to sense dynamic changes in composition and flow rates of protourine along the renal tubule. It is envisioned that Ca2+- permeable transient receptor potential (TRP) channels, and specifically mechanosensitive TRPV4, can serve to interpret these external mechanical cues in the form of elevated intracellular Ca2+ concentration. This, in turn, initiates multiple cellular responses and adaptation mechanisms. The current review summarizes up-to-date knowledge about the sites of TRPV4 expression in renal tissue as well as discusses the functional role of the channel in cellular responses to hypotonicity and tubular flow. We will also provide insights as to how TRPV4 fits into classical polycystin mechanosensory complex in cilia and will speculate about previously underappreciated clinical implication of pharmacological TRPV4 targeting in treatment of polycystic kidney disease.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalPflugers Archiv European Journal of Physiology
Volume465
Issue number2
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

Fingerprint

TRPP Cation Channels
Transient Receptor Potential Channels
Flow rate
Tissue
Kidney
Plasmas
Chemical analysis
Polycystic Kidney Diseases
Cilia
Nephrons
Cues
Homeostasis
Pharmacology

Keywords

  • Collecting duct
  • Connecting tubule
  • Hypotonicity
  • Intracellular Ca elevations
  • Polycystic kidney disease
  • Tubular flow

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Cite this

Novel insights into TRPV4 function in the kidney. / Pochynyuk, Oleh; Zaika, Oleg; O'Neil, Roger G.; Mamenko, Mykola.

In: Pflugers Archiv European Journal of Physiology, Vol. 465, No. 2, 01.02.2013, p. 177-186.

Research output: Contribution to journalReview article

Pochynyuk, Oleh ; Zaika, Oleg ; O'Neil, Roger G. ; Mamenko, Mykola. / Novel insights into TRPV4 function in the kidney. In: Pflugers Archiv European Journal of Physiology. 2013 ; Vol. 465, No. 2. pp. 177-186.
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