Abstract
Soon after adult rats receive unilateral chorda tympani nerve section in combination with dietary sodium restriction, neural taste responses recorded from the intact, contralateral chorda tympani nerve are substantially reduced. We hypothesized that the immune system is compromised in sodium- restricted rats, which leads to functional alterations in the peripheral taste system after neural injury. Here, immune function was stimulated with a systemic injection of lipopolysaccharide (LPS), and neurophysiological responses were recorded from the uncut chorda tympani 4-10 days after nerve section to determine if normal sodium sensitivity was restored. Rats receiving nerve section, dietary sodium restriction, and LPS exhibited normal sodium responses. In intact rats, injection of LPS alone or LPS injection combined with sodium restriction had no effect on taste responses to sodium stimuli. Surprisingly, combining nerve section, LPS injection, and maintenance of rats on a normal diet induced supersensitive responses to sodium. These findings are the first to demonstrate that the immune system can regulate peripheral gustatory function.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| Volume | 271 |
| Issue number | 4 40-4 |
| State | Published - Oct 1 1996 |
| Externally published | Yes |
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Keywords
- amiloride
- chorda tympani nerve
- electrophysiology
- neural degeneration
- neuroimmunology
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Novel regulation of peripheral gustatory function by the immune system. / McCluskey, Lynnette; Hill, David L.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 271, No. 4 40-4, 01.10.1996.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Novel regulation of peripheral gustatory function by the immune system
AU - McCluskey, Lynnette
AU - Hill, David L.
PY - 1996/10/1
Y1 - 1996/10/1
N2 - Soon after adult rats receive unilateral chorda tympani nerve section in combination with dietary sodium restriction, neural taste responses recorded from the intact, contralateral chorda tympani nerve are substantially reduced. We hypothesized that the immune system is compromised in sodium- restricted rats, which leads to functional alterations in the peripheral taste system after neural injury. Here, immune function was stimulated with a systemic injection of lipopolysaccharide (LPS), and neurophysiological responses were recorded from the uncut chorda tympani 4-10 days after nerve section to determine if normal sodium sensitivity was restored. Rats receiving nerve section, dietary sodium restriction, and LPS exhibited normal sodium responses. In intact rats, injection of LPS alone or LPS injection combined with sodium restriction had no effect on taste responses to sodium stimuli. Surprisingly, combining nerve section, LPS injection, and maintenance of rats on a normal diet induced supersensitive responses to sodium. These findings are the first to demonstrate that the immune system can regulate peripheral gustatory function.
AB - Soon after adult rats receive unilateral chorda tympani nerve section in combination with dietary sodium restriction, neural taste responses recorded from the intact, contralateral chorda tympani nerve are substantially reduced. We hypothesized that the immune system is compromised in sodium- restricted rats, which leads to functional alterations in the peripheral taste system after neural injury. Here, immune function was stimulated with a systemic injection of lipopolysaccharide (LPS), and neurophysiological responses were recorded from the uncut chorda tympani 4-10 days after nerve section to determine if normal sodium sensitivity was restored. Rats receiving nerve section, dietary sodium restriction, and LPS exhibited normal sodium responses. In intact rats, injection of LPS alone or LPS injection combined with sodium restriction had no effect on taste responses to sodium stimuli. Surprisingly, combining nerve section, LPS injection, and maintenance of rats on a normal diet induced supersensitive responses to sodium. These findings are the first to demonstrate that the immune system can regulate peripheral gustatory function.
KW - amiloride
KW - chorda tympani nerve
KW - electrophysiology
KW - neural degeneration
KW - neuroimmunology
UR - http://www.scopus.com/inward/record.url?scp=0029999574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029999574&partnerID=8YFLogxK
M3 - Article
C2 - 8897974
AN - SCOPUS:0029999574
VL - 271
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
SN - 0363-6135
IS - 4 40-4
ER -