Novel signaling pathways contributing to vascular changes in hypertension

D. G. Johns, A. M. Dorrance, R. Leite, D. S. Weber, R Clinton Webb

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

In hypertension, increased peripheral resistance maintains elevated levels of arterial blood pressure. The increase in peripheral ressitance results, in part, from abnormal constrictor and dilator responses and vascular remodeling. In this review, we consider four cellular signaling pathways as possible explanations for these abnormal vascular responses: (1) augmented signaling via the epidermal growth factor receptor to cause remodeling of the cerebrovasculature; (2) reduced sphingolipid signaling leading to blunted vasodilation and increased smooth muscle proliferation; (3) increased signaling via Rho/Rho kinase leading to enhanced vasoconstriction, and (4) a relative state of microtubular depolymerization favoring vasoconstriction in hypertension. These novel cell signaling pathways provide new pharmacological targets to reduce total peripheral vascular resistance in hypertension. Copyright (C) 2000 National Science Council.

Original languageEnglish (US)
Pages (from-to)431-443
Number of pages13
JournalJournal of Biomedical Science
Volume7
Issue number6
DOIs
StatePublished - Jan 1 2000

Fingerprint

Vascular Resistance
Cell signaling
Blood Vessels
Hypertension
Vasoconstriction
rho-Associated Kinases
Depolymerization
Sphingolipids
Blood pressure
Epidermal Growth Factor Receptor
Vasodilation
Smooth Muscle
Muscle
Arterial Pressure
Pharmacology
Vascular Remodeling

Keywords

  • Ceramide
  • Epidermal growth factor
  • GTP binding proteins
  • Microtubules
  • Vascular smooth muscle

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Novel signaling pathways contributing to vascular changes in hypertension. / Johns, D. G.; Dorrance, A. M.; Leite, R.; Weber, D. S.; Webb, R Clinton.

In: Journal of Biomedical Science, Vol. 7, No. 6, 01.01.2000, p. 431-443.

Research output: Contribution to journalReview article

Johns, D. G. ; Dorrance, A. M. ; Leite, R. ; Weber, D. S. ; Webb, R Clinton. / Novel signaling pathways contributing to vascular changes in hypertension. In: Journal of Biomedical Science. 2000 ; Vol. 7, No. 6. pp. 431-443.
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