Abstract
A series of 2,4-diphenylthiazole derivatives were synthesized and directly fluorinated at the 5-position by reaction with the N-F fluorinating reagent Accufluor®. Although fluorination occurred selectively at the thiazole ring, it was always incomplete and thus yields for the novel fluorinated products were low to moderate (19-43%) following purification to remove starting material. Nonetheless, the target compounds were obtained in a convenient and straightforward manner. Selectfluor® was not as effective as Accufluor® as it gave a trace amount of the 5-chlorothiazole that was difficult to remove by chromatography.
Original language | English (US) |
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Pages (from-to) | 1591-1594 |
Number of pages | 4 |
Journal | Journal of Fluorine Chemistry |
Volume | 127 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2006 |
Externally published | Yes |
Keywords
- Accufluor
- Fluorination
- Selectfluor
- Substituent effects
- Thiazole
ASJC Scopus subject areas
- Biochemistry
- Environmental Chemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry