Nutrition in intestinal failure/short bowel syndrome

Jatinder J Bhatia, Cynthia Mundy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Intestinal failure is the critical reduction of functional gut mass below the minimal amount necessary for adequate digestion and absorption to satisfy body nutrient and fluid requirements for maintenance and growth in children and adults. Short-bowel syndrome (SBS) is the most common cause of intestinal failure in infants, and results from surgical resection, congenital defect, or disease-associated loss of absorption capacity of the gut. It is characterized by the inability to maintain protein-energy, fluid, electrolyte, or micronutrient balances when on a conventionally accepted, normal diet, resulting in dependence on parenteral nutrition (PN). The duration of PN significantly correlates with the length of residual gut. The most common cause of SBS (35-50∈% of cases) in the neonatal period is necrotizing enterocolitis. The other causes include abdominal wall defects such as gastroschisis, and omphalocele, midgut volvulus, and intestinal atresia. Approximately, 80∈% of SBS in the paediatric population occurs in the neonatal period. The health burden of SBS is significant with high mortality (27.5-37.5∈%), and morbidity including recurrent bouts of sepsis needing hospitalisation, prolonged hospital stay, impaired long term growth and development, and high cost of care. The pathophysiology, mechanisms of intestinal adaptation, and management of SBS are reviewed.

Original languageEnglish (US)
Title of host publicationNutrition for the Preterm Neonate
Subtitle of host publicationA Clinical Perspective
PublisherSpringer Netherlands
Pages405-420
Number of pages16
ISBN (Electronic)9789400768123
ISBN (Print)9400768117, 9789400768116
DOIs
StatePublished - Nov 1 2013

Fingerprint

Short Bowel Syndrome
Parenteral Nutrition
Intestinal Atresia
Gastroschisis
Umbilical Hernia
Necrotizing Enterocolitis
Micronutrients
Body Fluids
Abdominal Wall
Growth and Development
Electrolytes
Digestion
Length of Stay
Sepsis
Hospitalization
Maintenance
Pediatrics
Diet
Morbidity
Costs and Cost Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bhatia, J. J., & Mundy, C. (2013). Nutrition in intestinal failure/short bowel syndrome. In Nutrition for the Preterm Neonate: A Clinical Perspective (pp. 405-420). Springer Netherlands. https://doi.org/10.1007/978-94-007-6812-3_20

Nutrition in intestinal failure/short bowel syndrome. / Bhatia, Jatinder J; Mundy, Cynthia.

Nutrition for the Preterm Neonate: A Clinical Perspective. Springer Netherlands, 2013. p. 405-420.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bhatia, JJ & Mundy, C 2013, Nutrition in intestinal failure/short bowel syndrome. in Nutrition for the Preterm Neonate: A Clinical Perspective. Springer Netherlands, pp. 405-420. https://doi.org/10.1007/978-94-007-6812-3_20
Bhatia JJ, Mundy C. Nutrition in intestinal failure/short bowel syndrome. In Nutrition for the Preterm Neonate: A Clinical Perspective. Springer Netherlands. 2013. p. 405-420 https://doi.org/10.1007/978-94-007-6812-3_20
Bhatia, Jatinder J ; Mundy, Cynthia. / Nutrition in intestinal failure/short bowel syndrome. Nutrition for the Preterm Neonate: A Clinical Perspective. Springer Netherlands, 2013. pp. 405-420
@inbook{a1a380670d7b454eaa58080dc163a0e7,
title = "Nutrition in intestinal failure/short bowel syndrome",
abstract = "Intestinal failure is the critical reduction of functional gut mass below the minimal amount necessary for adequate digestion and absorption to satisfy body nutrient and fluid requirements for maintenance and growth in children and adults. Short-bowel syndrome (SBS) is the most common cause of intestinal failure in infants, and results from surgical resection, congenital defect, or disease-associated loss of absorption capacity of the gut. It is characterized by the inability to maintain protein-energy, fluid, electrolyte, or micronutrient balances when on a conventionally accepted, normal diet, resulting in dependence on parenteral nutrition (PN). The duration of PN significantly correlates with the length of residual gut. The most common cause of SBS (35-50∈{\%} of cases) in the neonatal period is necrotizing enterocolitis. The other causes include abdominal wall defects such as gastroschisis, and omphalocele, midgut volvulus, and intestinal atresia. Approximately, 80∈{\%} of SBS in the paediatric population occurs in the neonatal period. The health burden of SBS is significant with high mortality (27.5-37.5∈{\%}), and morbidity including recurrent bouts of sepsis needing hospitalisation, prolonged hospital stay, impaired long term growth and development, and high cost of care. The pathophysiology, mechanisms of intestinal adaptation, and management of SBS are reviewed.",
author = "Bhatia, {Jatinder J} and Cynthia Mundy",
year = "2013",
month = "11",
day = "1",
doi = "10.1007/978-94-007-6812-3_20",
language = "English (US)",
isbn = "9400768117",
pages = "405--420",
booktitle = "Nutrition for the Preterm Neonate",
publisher = "Springer Netherlands",

}

TY - CHAP

T1 - Nutrition in intestinal failure/short bowel syndrome

AU - Bhatia, Jatinder J

AU - Mundy, Cynthia

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Intestinal failure is the critical reduction of functional gut mass below the minimal amount necessary for adequate digestion and absorption to satisfy body nutrient and fluid requirements for maintenance and growth in children and adults. Short-bowel syndrome (SBS) is the most common cause of intestinal failure in infants, and results from surgical resection, congenital defect, or disease-associated loss of absorption capacity of the gut. It is characterized by the inability to maintain protein-energy, fluid, electrolyte, or micronutrient balances when on a conventionally accepted, normal diet, resulting in dependence on parenteral nutrition (PN). The duration of PN significantly correlates with the length of residual gut. The most common cause of SBS (35-50∈% of cases) in the neonatal period is necrotizing enterocolitis. The other causes include abdominal wall defects such as gastroschisis, and omphalocele, midgut volvulus, and intestinal atresia. Approximately, 80∈% of SBS in the paediatric population occurs in the neonatal period. The health burden of SBS is significant with high mortality (27.5-37.5∈%), and morbidity including recurrent bouts of sepsis needing hospitalisation, prolonged hospital stay, impaired long term growth and development, and high cost of care. The pathophysiology, mechanisms of intestinal adaptation, and management of SBS are reviewed.

AB - Intestinal failure is the critical reduction of functional gut mass below the minimal amount necessary for adequate digestion and absorption to satisfy body nutrient and fluid requirements for maintenance and growth in children and adults. Short-bowel syndrome (SBS) is the most common cause of intestinal failure in infants, and results from surgical resection, congenital defect, or disease-associated loss of absorption capacity of the gut. It is characterized by the inability to maintain protein-energy, fluid, electrolyte, or micronutrient balances when on a conventionally accepted, normal diet, resulting in dependence on parenteral nutrition (PN). The duration of PN significantly correlates with the length of residual gut. The most common cause of SBS (35-50∈% of cases) in the neonatal period is necrotizing enterocolitis. The other causes include abdominal wall defects such as gastroschisis, and omphalocele, midgut volvulus, and intestinal atresia. Approximately, 80∈% of SBS in the paediatric population occurs in the neonatal period. The health burden of SBS is significant with high mortality (27.5-37.5∈%), and morbidity including recurrent bouts of sepsis needing hospitalisation, prolonged hospital stay, impaired long term growth and development, and high cost of care. The pathophysiology, mechanisms of intestinal adaptation, and management of SBS are reviewed.

UR - http://www.scopus.com/inward/record.url?scp=84928857666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928857666&partnerID=8YFLogxK

U2 - 10.1007/978-94-007-6812-3_20

DO - 10.1007/978-94-007-6812-3_20

M3 - Chapter

AN - SCOPUS:84928857666

SN - 9400768117

SN - 9789400768116

SP - 405

EP - 420

BT - Nutrition for the Preterm Neonate

PB - Springer Netherlands

ER -