Obesity associated Lyplal1 gene is regulated in diet induced obesity but not required for adipocyte differentiation

Xinnuo Lei, Mayson Callaway, Hongyi Zhou, Yi Yang, Weiqin Chen

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Obesity and its associated morbidities represent one of the major and most rapidly expanding health epidemics in the world. Recent genome-wide association studies (GWAS) have identified several variants in LYPLAL1 gene that are significantly associated with central obesity preferentially in females. However, the exact function of this gene in adipose tissue development and obesity remains completely uncharacterized. We found murine Lyplal1 gene demonstrated a depot and sex-specific expression profile in white adipose tissues (WAT), and was significantly reduced in the epididymal and retroperitoneal fats in a murine model of high fat diet induced obesity (DIO). Lyplal1 mRNA was mildly up-regulated during adipogenesis and enriched in mature adipocytes through a PPARγ-independent mechanism. However, overexpression and knockdown of Lyplal1 did not significantly perturb adipocyte differentiation, triacylglycerol accumulation and/or insulin signaling. These data highlight a depot-specific marked reduction of Lyplal1 transcripts in diet induced obesity but a dispensable role of Lyplal1 in adipose tissue development.

Original languageEnglish (US)
Pages (from-to)207-213
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume411
DOIs
StatePublished - Aug 5 2015

Keywords

  • Adipocyte differentiation
  • Fat distribution
  • Lyplal1
  • Obesity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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