Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity

Joanna R. Erion, Marlena Wosiski-Kuhn, Aditi Dey, Shuai Hao, Catherine L. Davis, Norman K. Pollock, Alexis M. Stranahan

Research output: Contribution to journalArticle

154 Scopus citations

Abstract

Adipose tissue is a known source of proinflammatory cytokines in obese humans and animal models, including the db/db mouse, in which obesity arises as a result of leptin receptor insensitivity. Inflammatory cytokines induce cognitive deficits across numerous conditions, but no studies have determined whether obesity-induced inflammation mediates synaptic dysfunction. To address this question, we used a treadmill training paradigm in which mice were exposed to daily training sessions or an immobile belt, with motivation achieved by delivery of compressed air on noncompliance. Treadmill training prevented hippocampal microgliosis, abolished expression of microglial activation markers, and also blocked the functional sensitization observed in isolated cells after ex vivo exposure to lipopolysaccharide. Reduced microglial reactivity with exercise was associated with reinstatement of hippocampus-dependent memory, reversal of deficits in long-term potentiation, and normalization of hippocampal dendritic spine density. Because treadmill training evokes broad responses not limited to the immune system, we next assessed whether directly manipulating adiposity through lipectomy and fat transplantation influences inflammation, cognition, and synaptic plasticity. Lipectomy prevents and fat transplantation promotes systemic and central inflammation, with associated alterations in cognitive and synaptic function. Levels of interleukin 1β (IL1β) emerged as a correlate of adiposity and cognitive impairment across both the treadmill and lipectomy studies, so we manipulated hippocampal IL1 signaling using intrahippocampal delivery of IL1 receptor antagonist (IL1ra). Intrahippocampal IL1ra prevented synaptic dysfunction, proinflammatory priming, and cognitive impairment. This pattern supports a central role for IL1-mediated neuroinflammation as a mechanism for cognitive deficits in obesity and diabetes.

Original languageEnglish (US)
Pages (from-to)2618-2631
Number of pages14
JournalJournal of Neuroscience
Volume34
Issue number7
DOIs
StatePublished - 2014

Keywords

  • Diabetes
  • Hippocampus
  • Inflammation
  • Microglia
  • Obesity
  • Synapse

ASJC Scopus subject areas

  • Neuroscience(all)

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