Ocular Pharmacokinetics of Ceftriaxone Following Subconjunctival Injection in Rabbits

Walter M. Jay, Robert K. Shockley, Adel M. Aziz, Mervat Z. Aziz, J. Peter Rissing

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Aqueous and vitreous kinetics were studied after anterior subconjunctival injection of 100 mg of ceftriaxone sodium in phakic and aphakic rabbit eyes. Mean peak ceftriaxone concentrations (microgram per milliliter ± SE, n = 3 to 5 rabbits per determination) were as follows: phakic eyes, 159.5 ± 42 at one hour in aqueous humor and 25.3 ± 6.6 at two hours in vitreous fluid; aphakic eyes, 105.1 ± 20.5 at one hour in aqueous humor and 43.1 ± 15.4 at one hour in vitreous humor. The ability of ceftriaxone to eliminate an incipient bacterial infection was also evaluated. Ten aphakic rabbits were challenged intravitreally with 700 colony-forming units of Staphylococcus aureus Six of the ten immediately received subconjunctival injections of ceftriaxone sodium (100 mg). At 48 hours following the challenge, all four control eyes yielded greater than 5.6 × 105 colonies per milliliter. In the six eyes receiving ceftriaxone, five were sterile and one yielded 1.4 × 102 colonies per milliliter.

Original languageEnglish (US)
Pages (from-to)430-432
Number of pages3
JournalArchives of Ophthalmology
Volume102
Issue number3
DOIs
StatePublished - Jan 1 1984

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Ceftriaxone
Pharmacokinetics
Rabbits
Injections
Aqueous Humor
Vitreous Body
Bacterial Infections
Staphylococcus aureus
Stem Cells

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular Pharmacokinetics of Ceftriaxone Following Subconjunctival Injection in Rabbits. / Jay, Walter M.; Shockley, Robert K.; Aziz, Adel M.; Aziz, Mervat Z.; Peter Rissing, J.

In: Archives of Ophthalmology, Vol. 102, No. 3, 01.01.1984, p. 430-432.

Research output: Contribution to journalArticle

Jay, Walter M. ; Shockley, Robert K. ; Aziz, Adel M. ; Aziz, Mervat Z. ; Peter Rissing, J. / Ocular Pharmacokinetics of Ceftriaxone Following Subconjunctival Injection in Rabbits. In: Archives of Ophthalmology. 1984 ; Vol. 102, No. 3. pp. 430-432.
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