Old and new roles and evolving complexities of cardiovascular clocks

Yanyan Xu, Wenhu Pi, Radu Daniel Rudic

Research output: Contribution to journalReview article

Abstract

The cardiovascular (CV†) system has been established to be significantly influenced by the molecular components of circadian rhythm. Oscillations of circadian rhythm occur within the circulation to affect thrombosis and blood pressure and within CV tissues including arteries, heart, and kidney to control function. Physiologic and molecular oscillations of circadian rhythm have been well connected via global, tissue-specific, and transgenic reporter mouse models of key core clock signals such as Bmal1, Period, and Clock, which can produce both pathology and protection with their mutation. With different nuances of CV clock action continuing to emerge in studies of the cardiovascular system, new questions are raised in both new and old mouse model system observations that underscore the importance, complexity, and continued study of the circadian clock mechanism in cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalYale Journal of Biology and Medicine
Volume92
Issue number2
StatePublished - Jan 1 2019

Fingerprint

Circadian Rhythm
Clocks
Cardiovascular System
Cardiovascular system
Circadian Clocks
Tissue
Transgenic Mice
Blood pressure
Thrombosis
Pathology
Cardiovascular Diseases
Arteries
Blood Pressure
Kidney
Mutation

Keywords

  • Blood pressure
  • Bmal1
  • Cardiovascular
  • Circadian
  • Clock

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Old and new roles and evolving complexities of cardiovascular clocks. / Xu, Yanyan; Pi, Wenhu; Rudic, Radu Daniel.

In: Yale Journal of Biology and Medicine, Vol. 92, No. 2, 01.01.2019, p. 283-290.

Research output: Contribution to journalReview article

@article{15012f3743f7468897f94528c2b729d2,
title = "Old and new roles and evolving complexities of cardiovascular clocks",
abstract = "The cardiovascular (CV†) system has been established to be significantly influenced by the molecular components of circadian rhythm. Oscillations of circadian rhythm occur within the circulation to affect thrombosis and blood pressure and within CV tissues including arteries, heart, and kidney to control function. Physiologic and molecular oscillations of circadian rhythm have been well connected via global, tissue-specific, and transgenic reporter mouse models of key core clock signals such as Bmal1, Period, and Clock, which can produce both pathology and protection with their mutation. With different nuances of CV clock action continuing to emerge in studies of the cardiovascular system, new questions are raised in both new and old mouse model system observations that underscore the importance, complexity, and continued study of the circadian clock mechanism in cardiovascular disease.",
keywords = "Blood pressure, Bmal1, Cardiovascular, Circadian, Clock",
author = "Yanyan Xu and Wenhu Pi and Rudic, {Radu Daniel}",
year = "2019",
month = "1",
day = "1",
language = "English (US)",
volume = "92",
pages = "283--290",
journal = "Yale Journal of Biology and Medicine",
issn = "0044-0086",
publisher = "Yale Journal of Biology and Medicine Inc.",
number = "2",

}

TY - JOUR

T1 - Old and new roles and evolving complexities of cardiovascular clocks

AU - Xu, Yanyan

AU - Pi, Wenhu

AU - Rudic, Radu Daniel

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The cardiovascular (CV†) system has been established to be significantly influenced by the molecular components of circadian rhythm. Oscillations of circadian rhythm occur within the circulation to affect thrombosis and blood pressure and within CV tissues including arteries, heart, and kidney to control function. Physiologic and molecular oscillations of circadian rhythm have been well connected via global, tissue-specific, and transgenic reporter mouse models of key core clock signals such as Bmal1, Period, and Clock, which can produce both pathology and protection with their mutation. With different nuances of CV clock action continuing to emerge in studies of the cardiovascular system, new questions are raised in both new and old mouse model system observations that underscore the importance, complexity, and continued study of the circadian clock mechanism in cardiovascular disease.

AB - The cardiovascular (CV†) system has been established to be significantly influenced by the molecular components of circadian rhythm. Oscillations of circadian rhythm occur within the circulation to affect thrombosis and blood pressure and within CV tissues including arteries, heart, and kidney to control function. Physiologic and molecular oscillations of circadian rhythm have been well connected via global, tissue-specific, and transgenic reporter mouse models of key core clock signals such as Bmal1, Period, and Clock, which can produce both pathology and protection with their mutation. With different nuances of CV clock action continuing to emerge in studies of the cardiovascular system, new questions are raised in both new and old mouse model system observations that underscore the importance, complexity, and continued study of the circadian clock mechanism in cardiovascular disease.

KW - Blood pressure

KW - Bmal1

KW - Cardiovascular

KW - Circadian

KW - Clock

UR - http://www.scopus.com/inward/record.url?scp=85068981350&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068981350&partnerID=8YFLogxK

M3 - Review article

C2 - 31249489

AN - SCOPUS:85068981350

VL - 92

SP - 283

EP - 290

JO - Yale Journal of Biology and Medicine

JF - Yale Journal of Biology and Medicine

SN - 0044-0086

IS - 2

ER -