Abstract
Effects of a benzodiazepine (chlordiazepoxide), an N-methyl-D-aspartate receptor antagonist (dizocilpine), and an opiate agonist (morphine) were studied with a procedure designed to assess effects of drugs and other manipulations on nonspatial learning in rats. In each session, rats were exposed to 2 different 2-choice odor-discrimination problems with food reinforcement for correct responses. One problem (performance discrimination) remained the same throughout the study. That is, 1 odor was always correct (S+) and the other was never correct (S-). For the other problem (reversal discrimination), stimuli changed every session. Six different odors were used to program the reversal discrimination; on any given session, S+ was a stimulus that had served as S- the last time it had appeared, S- was a stimulus that had been S+ on its last appearance. Thus, in each session, learning a discrimination reversal could be studied along with the performance of a comparable, but previously learned, discrimination. Chlordiazepoxide interfered with reversal learning at doses that had no effect on the performance discrimination. Morphine and dizocilpine also impaired reversal learning but only at doses that also affected performance of the well-learned performance discrimination.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1175-1179 |
| Number of pages | 5 |
| Journal | Behavioral Neuroscience |
| Volume | 120 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1 2006 |
| Externally published | Yes |
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Keywords
- Benzodiazepine
- Learning
- Morphine
- NMDA antagonist
- Odor discrimination
- Repeated acquisition
ASJC Scopus subject areas
- Behavioral Neuroscience
Cite this
Olfactory repeated discrimination reversal in rats : Effects of chlordiazepoxide, dizocilpine, and morphine. / Galizio, Mark; Miller, Laurence L; Ferguson, Adam; McKinney, Patrick; Pitts, Raymond C.
In: Behavioral Neuroscience, Vol. 120, No. 5, 01.10.2006, p. 1175-1179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Olfactory repeated discrimination reversal in rats
T2 - Effects of chlordiazepoxide, dizocilpine, and morphine
AU - Galizio, Mark
AU - Miller, Laurence L
AU - Ferguson, Adam
AU - McKinney, Patrick
AU - Pitts, Raymond C.
PY - 2006/10/1
Y1 - 2006/10/1
N2 - Effects of a benzodiazepine (chlordiazepoxide), an N-methyl-D-aspartate receptor antagonist (dizocilpine), and an opiate agonist (morphine) were studied with a procedure designed to assess effects of drugs and other manipulations on nonspatial learning in rats. In each session, rats were exposed to 2 different 2-choice odor-discrimination problems with food reinforcement for correct responses. One problem (performance discrimination) remained the same throughout the study. That is, 1 odor was always correct (S+) and the other was never correct (S-). For the other problem (reversal discrimination), stimuli changed every session. Six different odors were used to program the reversal discrimination; on any given session, S+ was a stimulus that had served as S- the last time it had appeared, S- was a stimulus that had been S+ on its last appearance. Thus, in each session, learning a discrimination reversal could be studied along with the performance of a comparable, but previously learned, discrimination. Chlordiazepoxide interfered with reversal learning at doses that had no effect on the performance discrimination. Morphine and dizocilpine also impaired reversal learning but only at doses that also affected performance of the well-learned performance discrimination.
AB - Effects of a benzodiazepine (chlordiazepoxide), an N-methyl-D-aspartate receptor antagonist (dizocilpine), and an opiate agonist (morphine) were studied with a procedure designed to assess effects of drugs and other manipulations on nonspatial learning in rats. In each session, rats were exposed to 2 different 2-choice odor-discrimination problems with food reinforcement for correct responses. One problem (performance discrimination) remained the same throughout the study. That is, 1 odor was always correct (S+) and the other was never correct (S-). For the other problem (reversal discrimination), stimuli changed every session. Six different odors were used to program the reversal discrimination; on any given session, S+ was a stimulus that had served as S- the last time it had appeared, S- was a stimulus that had been S+ on its last appearance. Thus, in each session, learning a discrimination reversal could be studied along with the performance of a comparable, but previously learned, discrimination. Chlordiazepoxide interfered with reversal learning at doses that had no effect on the performance discrimination. Morphine and dizocilpine also impaired reversal learning but only at doses that also affected performance of the well-learned performance discrimination.
KW - Benzodiazepine
KW - Learning
KW - Morphine
KW - NMDA antagonist
KW - Odor discrimination
KW - Repeated acquisition
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UR - http://www.scopus.com/inward/citedby.url?scp=33750072324&partnerID=8YFLogxK
U2 - 10.1037/0735-7044.120.5.1175
DO - 10.1037/0735-7044.120.5.1175
M3 - Article
C2 - 17014269
AN - SCOPUS:33750072324
VL - 120
SP - 1175
EP - 1179
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
SN - 0735-7044
IS - 5
ER -