On-road driving impairments in Huntington disease

Hannes Devos, Alice Nieuwboer, Wim Vandenberghe, Mark Tant, Willy De Weerdt, Ergun Y. Uc

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To determine the driving skill impairments and underlying visual, motor, and cognitive deficits that lead to failure on road testing in manifest Huntington disease (HD). Methods: Certified driving assessment experts scored performance on 13 specific on-road driving skills in 30 persons with HD and 30 controls and issued a pass/fail decision based on their overall impression. These on-road skill items were mapped onto an existing theoretical framework that categorized driving skills into operational, tactical, visuo-integrative, and mixed clusters. The HD group additionally completed a detailed off-road battery of motor, visual, and neuropsychological tests. Results: The HD group performed worse on all on-road items. Fourteen drivers with HD (47%) failed the road test compared with none of the controls. Scores on the Total Functional Capacity scale discriminated significantly between pass and fail groups. Total on-road score and performance in operational, tactical, and visuo-integrative clusters correlated strongly (Spearman ρ >0.50)with the pass/fail decision. The off-road tests showed variable strengths of association depending on the level of driving skill. Selective attention was strongly associated (Spearman ρ >0.50) with the total on-road score and all driving clusters. Conclusions: HD affects driving at many levels due to motor and cognitive deficits and leads to unsafe road performance even in mild stages. The high failure rate on the road test and difficulties in all aspects of on-road driving suggest that monitoring of fitness to drive should be initiated in the early course of HD.

Original languageEnglish (US)
Pages (from-to)956-962
Number of pages7
JournalNeurology
Volume82
Issue number11
DOIs
StatePublished - Mar 18 2014

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Huntington Disease
Neuropsychological Tests
Vision Disorders

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Devos, H., Nieuwboer, A., Vandenberghe, W., Tant, M., De Weerdt, W., & Uc, E. Y. (2014). On-road driving impairments in Huntington disease. Neurology, 82(11), 956-962. https://doi.org/10.1212/WNL.0000000000000220

On-road driving impairments in Huntington disease. / Devos, Hannes; Nieuwboer, Alice; Vandenberghe, Wim; Tant, Mark; De Weerdt, Willy; Uc, Ergun Y.

In: Neurology, Vol. 82, No. 11, 18.03.2014, p. 956-962.

Research output: Contribution to journalArticle

Devos, H, Nieuwboer, A, Vandenberghe, W, Tant, M, De Weerdt, W & Uc, EY 2014, 'On-road driving impairments in Huntington disease', Neurology, vol. 82, no. 11, pp. 956-962. https://doi.org/10.1212/WNL.0000000000000220
Devos H, Nieuwboer A, Vandenberghe W, Tant M, De Weerdt W, Uc EY. On-road driving impairments in Huntington disease. Neurology. 2014 Mar 18;82(11):956-962. https://doi.org/10.1212/WNL.0000000000000220
Devos, Hannes ; Nieuwboer, Alice ; Vandenberghe, Wim ; Tant, Mark ; De Weerdt, Willy ; Uc, Ergun Y. / On-road driving impairments in Huntington disease. In: Neurology. 2014 ; Vol. 82, No. 11. pp. 956-962.
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