Abstract
Background Altered coagulation function after trauma can contribute to development of venous thromboembolism (VTE). Severe trauma impairs coagulation function, but the trajectory for recovery is not known. We hypothesized that enhanced, early recovery of coagulation function increases VTE risk in severely injured trauma patients. Study Design Secondary analysis was performed on data from the Pragmatic Randomized Optimal Platelet and Plasma Ratio (PROPPR) trial, excluding patients who died within 24 hours or were on pre-injury anticoagulants. Patient characteristics, adverse outcomes, and parameters of platelet function and coagulation (thromboelastography) were compared from admission to 72 hours between VTE (n = 83) and non-VTE (n = 475) patients. A p value < 0.05 indicates significance. Results Despite similar patient demographics, VTE patients exhibited hypercoagulable thromboelastography parameters and enhanced platelet function at admission (p < 0.05). Both groups exhibited hypocoagulable thromboelastography parameters, platelet dysfunction, and suppressed clot lysis (low clot lysis at 30 minutes) 2 hours after admission (p < 0.05). The VTE patients exhibited delayed coagulation recovery (a significant change compared with 2 hours) of K-value (48 vs 24 hours), α-angle (no recovery), maximum amplitude (24 vs 12 hours), and clot lysis at 30 minutes (48 vs 12 hours). Platelet function recovery mediated by arachidonic acid (72 vs 4 hours), ADP (72 vs 12 hours), and collagen (48 vs 12 hours) was delayed in VTE patients. The VTE patients had lower mortality (4% vs 13%; p < 0.05), but fewer hospital-free days (0 days [interquartile range 0 to 8 days] vs 10 days [interquartile range 0 to 20 days]; p < 0.05) and higher complication rates (p < 0.05). Conclusions Recovery from platelet dysfunction and coagulopathy after severe trauma were delayed in VTE patients. Suppressed clot lysis and compensatory mechanisms associated with altered coagulation that can potentiate VTE formation require additional investigation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 42-51 |
| Number of pages | 10 |
| Journal | Journal of the American College of Surgeons |
| Volume | 225 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1 2017 |
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ASJC Scopus subject areas
- Surgery
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Research output: Contribution to journal › Article
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TY - JOUR
T1 - Onset of Coagulation Function Recovery Is Delayed in Severely Injured Trauma Patients with Venous Thromboembolism
AU - and the
AU - McCully, Belinda H.
AU - Connelly, Christopher R.
AU - Fair, Kelly A.
AU - Holcomb, John B.
AU - Fox, Erin E.
AU - Wade, Charles E.
AU - Bulger, Eileen M.
AU - Schreiber, Martin A.
AU - Holcomb, John B.
AU - Wade, Charles E.
AU - del Junco, Deborah J.
AU - Fox, Erin E.
AU - Matijevic, Nena
AU - Podbielski, Jeanette
AU - Beeler, Angela M.
AU - Tilley, Barbara C.
AU - Baraniuk, Sarah
AU - Nixon, Joshua
AU - Seay, Roann
AU - Appana, Savitri N.
AU - Yang, Hui
AU - Gonzalez, Michael O.
AU - Baer, Lisa
AU - Willa Wang, Yao Wei
AU - Hula, Brittany S.
AU - Espino, Elena
AU - Nguyen, An
AU - Pawelczyk, Nicholas
AU - Arora-Nutall, Kisha D.
AU - Sharma, Rishika
AU - Cardenas, Jessica C.
AU - Rahbar, Elaheh
AU - Burnett, Tyrone
AU - Clark, David
AU - van Belle, Gerald
AU - May, Susanne
AU - Leroux, Brian
AU - Hoyt, David
AU - Powell, Judy
AU - Sheehan, Kellie
AU - Hubbard, Alan
AU - Arkin, Adam P.
AU - Hess, John R.
AU - Callum, Jeanne
AU - Cotton, Bryan A.
AU - Vincent, Laura
AU - Welch, Timothy
AU - Poole, Tiffany
AU - Pivalizza, Evan G.
AU - OKeeffe, Terence
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background Altered coagulation function after trauma can contribute to development of venous thromboembolism (VTE). Severe trauma impairs coagulation function, but the trajectory for recovery is not known. We hypothesized that enhanced, early recovery of coagulation function increases VTE risk in severely injured trauma patients. Study Design Secondary analysis was performed on data from the Pragmatic Randomized Optimal Platelet and Plasma Ratio (PROPPR) trial, excluding patients who died within 24 hours or were on pre-injury anticoagulants. Patient characteristics, adverse outcomes, and parameters of platelet function and coagulation (thromboelastography) were compared from admission to 72 hours between VTE (n = 83) and non-VTE (n = 475) patients. A p value < 0.05 indicates significance. Results Despite similar patient demographics, VTE patients exhibited hypercoagulable thromboelastography parameters and enhanced platelet function at admission (p < 0.05). Both groups exhibited hypocoagulable thromboelastography parameters, platelet dysfunction, and suppressed clot lysis (low clot lysis at 30 minutes) 2 hours after admission (p < 0.05). The VTE patients exhibited delayed coagulation recovery (a significant change compared with 2 hours) of K-value (48 vs 24 hours), α-angle (no recovery), maximum amplitude (24 vs 12 hours), and clot lysis at 30 minutes (48 vs 12 hours). Platelet function recovery mediated by arachidonic acid (72 vs 4 hours), ADP (72 vs 12 hours), and collagen (48 vs 12 hours) was delayed in VTE patients. The VTE patients had lower mortality (4% vs 13%; p < 0.05), but fewer hospital-free days (0 days [interquartile range 0 to 8 days] vs 10 days [interquartile range 0 to 20 days]; p < 0.05) and higher complication rates (p < 0.05). Conclusions Recovery from platelet dysfunction and coagulopathy after severe trauma were delayed in VTE patients. Suppressed clot lysis and compensatory mechanisms associated with altered coagulation that can potentiate VTE formation require additional investigation.
AB - Background Altered coagulation function after trauma can contribute to development of venous thromboembolism (VTE). Severe trauma impairs coagulation function, but the trajectory for recovery is not known. We hypothesized that enhanced, early recovery of coagulation function increases VTE risk in severely injured trauma patients. Study Design Secondary analysis was performed on data from the Pragmatic Randomized Optimal Platelet and Plasma Ratio (PROPPR) trial, excluding patients who died within 24 hours or were on pre-injury anticoagulants. Patient characteristics, adverse outcomes, and parameters of platelet function and coagulation (thromboelastography) were compared from admission to 72 hours between VTE (n = 83) and non-VTE (n = 475) patients. A p value < 0.05 indicates significance. Results Despite similar patient demographics, VTE patients exhibited hypercoagulable thromboelastography parameters and enhanced platelet function at admission (p < 0.05). Both groups exhibited hypocoagulable thromboelastography parameters, platelet dysfunction, and suppressed clot lysis (low clot lysis at 30 minutes) 2 hours after admission (p < 0.05). The VTE patients exhibited delayed coagulation recovery (a significant change compared with 2 hours) of K-value (48 vs 24 hours), α-angle (no recovery), maximum amplitude (24 vs 12 hours), and clot lysis at 30 minutes (48 vs 12 hours). Platelet function recovery mediated by arachidonic acid (72 vs 4 hours), ADP (72 vs 12 hours), and collagen (48 vs 12 hours) was delayed in VTE patients. The VTE patients had lower mortality (4% vs 13%; p < 0.05), but fewer hospital-free days (0 days [interquartile range 0 to 8 days] vs 10 days [interquartile range 0 to 20 days]; p < 0.05) and higher complication rates (p < 0.05). Conclusions Recovery from platelet dysfunction and coagulopathy after severe trauma were delayed in VTE patients. Suppressed clot lysis and compensatory mechanisms associated with altered coagulation that can potentiate VTE formation require additional investigation.
UR - http://www.scopus.com/inward/record.url?scp=85017347587&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017347587&partnerID=8YFLogxK
U2 - 10.1016/j.jamcollsurg.2017.03.001
DO - 10.1016/j.jamcollsurg.2017.03.001
M3 - Article
C2 - 28315812
AN - SCOPUS:85017347587
VL - 225
SP - 42
EP - 51
JO - Journal of the American College of Surgeons
JF - Journal of the American College of Surgeons
SN - 1072-7515
IS - 1
ER -