Onset of dyskinesia with adjunct ropinirole prolonged-release or additional levodopa in early Parkinson's disease

Ray L. Watts, Kelly E. Lyons, Rajesh Pahwa, Kapil Sethi, Matthew Stern, Robert A. Hauser, Warren Olanow, Alex M. Gray, Bryan Adams, Nancy L. Earl

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Levodopa-induced dyskinesia can result in significant functional disability and reduced quality of life in patients with Parkinson's disease (PD). The goal of this study was to determine if the addition of once-daily ropinirole 24-hour prolonged-release (n = 104) in PD patients not optimally controlled with levodopa after up to 3 years of therapy with less than 600 mg/d delays the onset of dyskinesia compared with increasing doses of levodopa (n = 104). During the study, 3% of the ropinirole prolonged-release group (mean dose 10 mg/d) and 17% of the levodopa group (mean additional dose 284 mg/d) developed dyskinesia (P < 0.001). There were no significant differences in change in Unified Parkinson's Disease Rating Scale activities of daily living or motor scores, suggesting comparable efficacy between the two treatments. Adverse events were comparable in the two groups with nausea, dizziness, insomnia, back pain, arthralgia, somnolence, fatigue, and pain most commonly reported. Ropinirole prolonged-release delayed the onset of dyskinesia with comparable efficacy to increased doses of levodopa in early PD patients not optimally controlled with levodopa.

Original languageEnglish (US)
Pages (from-to)858-866
Number of pages9
JournalMovement Disorders
Volume25
Issue number7
DOIs
StatePublished - May 15 2010

Keywords

  • Dyskinesia
  • Levodopa
  • Parkinson's disease
  • Ropinirole prolonged-release

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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