Onset of the nondepolarizing neuromuscular block in humans: Quantitative aspects

V. Nigrovic, Mounir F Banoub

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The purpose of our study was a unified description of the time course for the onset of the neuromuscular block produced by different muscle relaxants after bolus intravenous injections. The environment of the receptors on the motor end plate was assumed to be a part of the interstitial space of the muscle. A unified consideration of four muscle relaxants was accomplished by expressing the concentrations of each relaxant in the interstitial space as multiples of the relaxant's dissociation constant. A flow-limited model was developed to describe the time course of the relaxant's concentration in the interstitial space as a function of its plasma concentration, the plasma flow to the muscle, and the volume of the interstitial space. The results show that those relaxants whose plasma concentrations decrease rapidly achieve an earlier (4-8 min), but relatively lower, peak concentration in the interstitial space. The relaxants with more sustained plasma concentrations reach the peak concentration later, 9-16 min after the bolus intravenous injection. The model allows the interpretation of several observations encountered with the clinical use of the muscle relaxants.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalAnesthesia and Analgesia
Volume76
Issue number1
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Neuromuscular Blockade
Muscles
Intravenous Injections
Motor Endplate

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Onset of the nondepolarizing neuromuscular block in humans : Quantitative aspects. / Nigrovic, V.; Banoub, Mounir F.

In: Anesthesia and Analgesia, Vol. 76, No. 1, 01.01.1993, p. 85-91.

Research output: Contribution to journalArticle

Nigrovic, V. ; Banoub, Mounir F. / Onset of the nondepolarizing neuromuscular block in humans : Quantitative aspects. In: Anesthesia and Analgesia. 1993 ; Vol. 76, No. 1. pp. 85-91.
@article{365b7598262345218fce4d90a402ce33,
title = "Onset of the nondepolarizing neuromuscular block in humans: Quantitative aspects",
abstract = "The purpose of our study was a unified description of the time course for the onset of the neuromuscular block produced by different muscle relaxants after bolus intravenous injections. The environment of the receptors on the motor end plate was assumed to be a part of the interstitial space of the muscle. A unified consideration of four muscle relaxants was accomplished by expressing the concentrations of each relaxant in the interstitial space as multiples of the relaxant's dissociation constant. A flow-limited model was developed to describe the time course of the relaxant's concentration in the interstitial space as a function of its plasma concentration, the plasma flow to the muscle, and the volume of the interstitial space. The results show that those relaxants whose plasma concentrations decrease rapidly achieve an earlier (4-8 min), but relatively lower, peak concentration in the interstitial space. The relaxants with more sustained plasma concentrations reach the peak concentration later, 9-16 min after the bolus intravenous injection. The model allows the interpretation of several observations encountered with the clinical use of the muscle relaxants.",
author = "V. Nigrovic and Banoub, {Mounir F}",
year = "1993",
month = "1",
day = "1",
language = "English (US)",
volume = "76",
pages = "85--91",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Onset of the nondepolarizing neuromuscular block in humans

T2 - Quantitative aspects

AU - Nigrovic, V.

AU - Banoub, Mounir F

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The purpose of our study was a unified description of the time course for the onset of the neuromuscular block produced by different muscle relaxants after bolus intravenous injections. The environment of the receptors on the motor end plate was assumed to be a part of the interstitial space of the muscle. A unified consideration of four muscle relaxants was accomplished by expressing the concentrations of each relaxant in the interstitial space as multiples of the relaxant's dissociation constant. A flow-limited model was developed to describe the time course of the relaxant's concentration in the interstitial space as a function of its plasma concentration, the plasma flow to the muscle, and the volume of the interstitial space. The results show that those relaxants whose plasma concentrations decrease rapidly achieve an earlier (4-8 min), but relatively lower, peak concentration in the interstitial space. The relaxants with more sustained plasma concentrations reach the peak concentration later, 9-16 min after the bolus intravenous injection. The model allows the interpretation of several observations encountered with the clinical use of the muscle relaxants.

AB - The purpose of our study was a unified description of the time course for the onset of the neuromuscular block produced by different muscle relaxants after bolus intravenous injections. The environment of the receptors on the motor end plate was assumed to be a part of the interstitial space of the muscle. A unified consideration of four muscle relaxants was accomplished by expressing the concentrations of each relaxant in the interstitial space as multiples of the relaxant's dissociation constant. A flow-limited model was developed to describe the time course of the relaxant's concentration in the interstitial space as a function of its plasma concentration, the plasma flow to the muscle, and the volume of the interstitial space. The results show that those relaxants whose plasma concentrations decrease rapidly achieve an earlier (4-8 min), but relatively lower, peak concentration in the interstitial space. The relaxants with more sustained plasma concentrations reach the peak concentration later, 9-16 min after the bolus intravenous injection. The model allows the interpretation of several observations encountered with the clinical use of the muscle relaxants.

UR - http://www.scopus.com/inward/record.url?scp=0027499010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027499010&partnerID=8YFLogxK

M3 - Article

C2 - 8418747

AN - SCOPUS:0027499010

VL - 76

SP - 85

EP - 91

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 1

ER -