Ontogeny of pig discrete peyer's patches: Distribution and morphometric analysis

L. H.C. Makala, T. Kamada, Y. Nishikawa, H. Nagasawa, I. Igarashi, K. Fujisaki, N. Suzuki, T. Mikami, K. Haverson, M. Bailey, C. R. Stokes, P. W. Bland

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We investigated the development of lymphoid and non-lymphoid cells in discrete Peyer's patches (PP) of the pig using immuno-histology and image analysis. In new-born piglets discrete PP were mainly populated by CD2+, CD3+ T cells, and major histocompatibility complex class II+ cells, many of which were of macrophage and dendritic cell lineage. Four days after birth, cells were localized in defined regions: the follicle; the inter-follicular area and the dome region. Compartmentalization within the follicle started about 6 days after birth. The first signs of secondary follicles were seen from about 14 days. The pig discrete PP attained their mature structure at about 3 weeks after birth. Here we show that despite the demonstration at birth of the cell types that support antigen processing and presentation, PP did not fully differentiate morphologically until at least this time when antigen can be handled in an efficient manner.

Original languageEnglish (US)
Pages (from-to)275-282
Number of pages8
JournalPathobiology
Volume68
Issue number6
DOIs
StatePublished - Dec 1 2000

Fingerprint

Peyer's Patches
Swine
Parturition
Antigen Presentation
Cell Lineage
Major Histocompatibility Complex
Dendritic Cells
Histology
Macrophages
T-Lymphocytes
Antigens

Keywords

  • Discrete Peyer's patch
  • Morphometric analysis
  • Ontogeny
  • Pig

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Makala, L. H. C., Kamada, T., Nishikawa, Y., Nagasawa, H., Igarashi, I., Fujisaki, K., ... Bland, P. W. (2000). Ontogeny of pig discrete peyer's patches: Distribution and morphometric analysis. Pathobiology, 68(6), 275-282. https://doi.org/10.1159/000055938

Ontogeny of pig discrete peyer's patches : Distribution and morphometric analysis. / Makala, L. H.C.; Kamada, T.; Nishikawa, Y.; Nagasawa, H.; Igarashi, I.; Fujisaki, K.; Suzuki, N.; Mikami, T.; Haverson, K.; Bailey, M.; Stokes, C. R.; Bland, P. W.

In: Pathobiology, Vol. 68, No. 6, 01.12.2000, p. 275-282.

Research output: Contribution to journalArticle

Makala, LHC, Kamada, T, Nishikawa, Y, Nagasawa, H, Igarashi, I, Fujisaki, K, Suzuki, N, Mikami, T, Haverson, K, Bailey, M, Stokes, CR & Bland, PW 2000, 'Ontogeny of pig discrete peyer's patches: Distribution and morphometric analysis', Pathobiology, vol. 68, no. 6, pp. 275-282. https://doi.org/10.1159/000055938
Makala LHC, Kamada T, Nishikawa Y, Nagasawa H, Igarashi I, Fujisaki K et al. Ontogeny of pig discrete peyer's patches: Distribution and morphometric analysis. Pathobiology. 2000 Dec 1;68(6):275-282. https://doi.org/10.1159/000055938
Makala, L. H.C. ; Kamada, T. ; Nishikawa, Y. ; Nagasawa, H. ; Igarashi, I. ; Fujisaki, K. ; Suzuki, N. ; Mikami, T. ; Haverson, K. ; Bailey, M. ; Stokes, C. R. ; Bland, P. W. / Ontogeny of pig discrete peyer's patches : Distribution and morphometric analysis. In: Pathobiology. 2000 ; Vol. 68, No. 6. pp. 275-282.
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