Ontogeny of Pig Discrete Peyer's Patches: Expression of Surface Antigens

Levi H.C. Makala; Takenori Kamada; Hideyuki Nagasawa; Ikuo Igarashi; Kozo Fujisaki; Naoyoshi Suzuki; Takeshi Mikami; Karin Haverson; Michael Bailey; Christopher R. Stokes; Paul W. Bland

doi:10.1292/jvms.63.625

Ontogeny of Pig Discrete Peyer's Patches: Expression of Surface Antigens

Levi H.C. Makala, Takenori Kamada, Hideyuki Nagasawa, Ikuo Igarashi, Kozo Fujisaki, Naoyoshi Suzuki, Takeshi Mikami, Karin Haverson, Michael Bailey, Christopher R. Stokes, Paul W. Bland

Pediatric Hematology/Oncology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Leukocyte populations present in the discrete Peyer's patches (PP) of the pig were characterized from birth (Day 0) to day 35 after birth by immunohistochemistry and image analysis. Immediately after birth, cell membrane expression of CD2 and CD3, major histocompatibilty complex (MHC) class II (both SLA (swine leukocyte antigen) -DQ⁺ and SLA-DR⁺), CD21, 74-22-15 and surface immunoglobulin (sIg) were all demonstrable. Computer assisted morphometric techniques were used to confirm the significant expansion of these cell populations from birth onwards. The distribution of the cell types was not random but suggested a preferential retention of cells at specific sites. This implies a degree of organization of immunological cells within the discrete PP, enhancing the potential to mount immune responses in the most efficient manner.

Original language	English (US)
Pages (from-to)	625-636
Number of pages	12
Journal	Journal of Veterinary Medical Science
Volume	63
Issue number	6
DOIs	https://doi.org/10.1292/jvms.63.625
State	Published - Jun 2001

Keywords

Discrete Peyer's patch
Ontogeny
Surface antigen expression
Swine

ASJC Scopus subject areas

General Veterinary

Access to Document

10.1292/jvms.63.625

Cite this

@article{454d3a3ea55341f581be82e96d6d7631,

title = "Ontogeny of Pig Discrete Peyer's Patches: Expression of Surface Antigens",

abstract = "Leukocyte populations present in the discrete Peyer's patches (PP) of the pig were characterized from birth (Day 0) to day 35 after birth by immunohistochemistry and image analysis. Immediately after birth, cell membrane expression of CD2 and CD3, major histocompatibilty complex (MHC) class II (both SLA (swine leukocyte antigen) -DQ+ and SLA-DR+), CD21, 74-22-15 and surface immunoglobulin (sIg) were all demonstrable. Computer assisted morphometric techniques were used to confirm the significant expansion of these cell populations from birth onwards. The distribution of the cell types was not random but suggested a preferential retention of cells at specific sites. This implies a degree of organization of immunological cells within the discrete PP, enhancing the potential to mount immune responses in the most efficient manner.",

keywords = "Discrete Peyer's patch, Ontogeny, Surface antigen expression, Swine",

author = "Makala, {Levi H.C.} and Takenori Kamada and Hideyuki Nagasawa and Ikuo Igarashi and Kozo Fujisaki and Naoyoshi Suzuki and Takeshi Mikami and Karin Haverson and Michael Bailey and Stokes, {Christopher R.} and Bland, {Paul W.}",

year = "2001",

month = jun,

doi = "10.1292/jvms.63.625",

language = "English (US)",

volume = "63",

pages = "625--636",

journal = "Journal of Veterinary Medical Science",

issn = "0916-7250",

publisher = "Japanese Society of Veterinary Science",

number = "6",

}

TY - JOUR

T1 - Ontogeny of Pig Discrete Peyer's Patches

T2 - Expression of Surface Antigens

AU - Makala, Levi H.C.

AU - Kamada, Takenori

AU - Nagasawa, Hideyuki

AU - Igarashi, Ikuo

AU - Fujisaki, Kozo

AU - Suzuki, Naoyoshi

AU - Mikami, Takeshi

AU - Haverson, Karin

AU - Bailey, Michael

AU - Stokes, Christopher R.

AU - Bland, Paul W.

PY - 2001/6

Y1 - 2001/6

N2 - Leukocyte populations present in the discrete Peyer's patches (PP) of the pig were characterized from birth (Day 0) to day 35 after birth by immunohistochemistry and image analysis. Immediately after birth, cell membrane expression of CD2 and CD3, major histocompatibilty complex (MHC) class II (both SLA (swine leukocyte antigen) -DQ+ and SLA-DR+), CD21, 74-22-15 and surface immunoglobulin (sIg) were all demonstrable. Computer assisted morphometric techniques were used to confirm the significant expansion of these cell populations from birth onwards. The distribution of the cell types was not random but suggested a preferential retention of cells at specific sites. This implies a degree of organization of immunological cells within the discrete PP, enhancing the potential to mount immune responses in the most efficient manner.

AB - Leukocyte populations present in the discrete Peyer's patches (PP) of the pig were characterized from birth (Day 0) to day 35 after birth by immunohistochemistry and image analysis. Immediately after birth, cell membrane expression of CD2 and CD3, major histocompatibilty complex (MHC) class II (both SLA (swine leukocyte antigen) -DQ+ and SLA-DR+), CD21, 74-22-15 and surface immunoglobulin (sIg) were all demonstrable. Computer assisted morphometric techniques were used to confirm the significant expansion of these cell populations from birth onwards. The distribution of the cell types was not random but suggested a preferential retention of cells at specific sites. This implies a degree of organization of immunological cells within the discrete PP, enhancing the potential to mount immune responses in the most efficient manner.

KW - Discrete Peyer's patch

KW - Ontogeny

KW - Surface antigen expression

KW - Swine

UR - http://www.scopus.com/inward/record.url?scp=18044404838&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18044404838&partnerID=8YFLogxK

U2 - 10.1292/jvms.63.625

DO - 10.1292/jvms.63.625

M3 - Article

C2 - 11459008

AN - SCOPUS:18044404838

SN - 0916-7250

VL - 63

SP - 625

EP - 636

JO - Journal of Veterinary Medical Science

JF - Journal of Veterinary Medical Science

IS - 6

ER -

Ontogeny of Pig Discrete Peyer's Patches: Expression of Surface Antigens

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this