Ontogeny of Pig Discrete Peyer's Patches: Expression of Surface Antigens

Levi H.C. Makala, Takenori Kamada, Hideyuki Nagasawa, Ikuo Igarashi, Kozo Fujisaki, Naoyoshi Suzuki, Takeshi Mikami, Karin Haverson, Michael Bailey, Christopher R. Stokes, Paul W. Bland

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Leukocyte populations present in the discrete Peyer's patches (PP) of the pig were characterized from birth (Day 0) to day 35 after birth by immunohistochemistry and image analysis. Immediately after birth, cell membrane expression of CD2 and CD3, major histocompatibilty complex (MHC) class II (both SLA (swine leukocyte antigen) -DQ+ and SLA-DR+), CD21, 74-22-15 and surface immunoglobulin (sIg) were all demonstrable. Computer assisted morphometric techniques were used to confirm the significant expansion of these cell populations from birth onwards. The distribution of the cell types was not random but suggested a preferential retention of cells at specific sites. This implies a degree of organization of immunological cells within the discrete PP, enhancing the potential to mount immune responses in the most efficient manner.

Original languageEnglish (US)
Pages (from-to)625-636
Number of pages12
JournalJournal of Veterinary Medical Science
Volume63
Issue number6
DOIs
StatePublished - Jun 1 2001

Fingerprint

Peyer's Patches
Peyer's patches
surface antigens
Surface Antigens
ontogeny
Swine
Parturition
leukocytes
swine
cells
antigens
B-Cell Antigen Receptors
immunoglobulins
Population
immunohistochemistry
cell membranes
Leukocytes
Immunohistochemistry
Cell Membrane
immune response

Keywords

  • Discrete Peyer's patch
  • Ontogeny
  • Surface antigen expression
  • Swine

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Makala, L. H. C., Kamada, T., Nagasawa, H., Igarashi, I., Fujisaki, K., Suzuki, N., ... Bland, P. W. (2001). Ontogeny of Pig Discrete Peyer's Patches: Expression of Surface Antigens. Journal of Veterinary Medical Science, 63(6), 625-636. https://doi.org/10.1292/jvms.63.625

Ontogeny of Pig Discrete Peyer's Patches : Expression of Surface Antigens. / Makala, Levi H.C.; Kamada, Takenori; Nagasawa, Hideyuki; Igarashi, Ikuo; Fujisaki, Kozo; Suzuki, Naoyoshi; Mikami, Takeshi; Haverson, Karin; Bailey, Michael; Stokes, Christopher R.; Bland, Paul W.

In: Journal of Veterinary Medical Science, Vol. 63, No. 6, 01.06.2001, p. 625-636.

Research output: Contribution to journalArticle

Makala, LHC, Kamada, T, Nagasawa, H, Igarashi, I, Fujisaki, K, Suzuki, N, Mikami, T, Haverson, K, Bailey, M, Stokes, CR & Bland, PW 2001, 'Ontogeny of Pig Discrete Peyer's Patches: Expression of Surface Antigens', Journal of Veterinary Medical Science, vol. 63, no. 6, pp. 625-636. https://doi.org/10.1292/jvms.63.625
Makala LHC, Kamada T, Nagasawa H, Igarashi I, Fujisaki K, Suzuki N et al. Ontogeny of Pig Discrete Peyer's Patches: Expression of Surface Antigens. Journal of Veterinary Medical Science. 2001 Jun 1;63(6):625-636. https://doi.org/10.1292/jvms.63.625
Makala, Levi H.C. ; Kamada, Takenori ; Nagasawa, Hideyuki ; Igarashi, Ikuo ; Fujisaki, Kozo ; Suzuki, Naoyoshi ; Mikami, Takeshi ; Haverson, Karin ; Bailey, Michael ; Stokes, Christopher R. ; Bland, Paul W. / Ontogeny of Pig Discrete Peyer's Patches : Expression of Surface Antigens. In: Journal of Veterinary Medical Science. 2001 ; Vol. 63, No. 6. pp. 625-636.
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