Ontogeny of Pig Discrete Peyer's Patches: Expression of Surface Antigens

Levi H.C. Makala, Takenori Kamada, Hideyuki Nagasawa, Ikuo Igarashi, Kozo Fujisaki, Naoyoshi Suzuki, Takeshi Mikami, Karin Haverson, Michael Bailey, Christopher R. Stokes, Paul W. Bland

11 Scopus citations

Abstract

Leukocyte populations present in the discrete Peyer's patches (PP) of the pig were characterized from birth (Day 0) to day 35 after birth by immunohistochemistry and image analysis. Immediately after birth, cell membrane expression of CD2 and CD3, major histocompatibilty complex (MHC) class II (both SLA (swine leukocyte antigen) -DQ+ and SLA-DR+), CD21, 74-22-15 and surface immunoglobulin (sIg) were all demonstrable. Computer assisted morphometric techniques were used to confirm the significant expansion of these cell populations from birth onwards. The distribution of the cell types was not random but suggested a preferential retention of cells at specific sites. This implies a degree of organization of immunological cells within the discrete PP, enhancing the potential to mount immune responses in the most efficient manner.

Original languageEnglish (US)
Pages (from-to)625-636
Number of pages12
JournalJournal of Veterinary Medical Science
Volume63
Issue number6
DOIs
Publication statusPublished - Jun 1 2001

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Keywords

  • Discrete Peyer's patch
  • Ontogeny
  • Surface antigen expression
  • Swine

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Makala, L. H. C., Kamada, T., Nagasawa, H., Igarashi, I., Fujisaki, K., Suzuki, N., ... Bland, P. W. (2001). Ontogeny of Pig Discrete Peyer's Patches: Expression of Surface Antigens. Journal of Veterinary Medical Science, 63(6), 625-636. https://doi.org/10.1292/jvms.63.625