Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients

Anvita Kale, Sadhana Joshi, Nilesh Naphade, Swati Sapkale, M. S.V.K. Raju, Anilkumar Pillai, Henry Nasrallah, Sahebarao P. Mahadik

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Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls matched for ethnicity, diet and life style. The plasma EPUFAs levels were similar in both groups. Among the EPUFAs enriched in the brain, predominantly docosahexaenoic acid (DHA) levels were lower in RBC (p = < 0.01) whereas higher in CSF (p = < 0.01) in male > female patients. This altered DHA metabolism may provide clues for neuropathology and treatment of schizophrenia.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalSchizophrenia Research
Issue number1-3
StatePublished - Jan 1 2008



  • Arachidonic acid
  • Cerebrospinal fluid
  • Docosahexaenoic acid
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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