Oral precancerous and malignant lesions associated with graft-versus-host disease: Report of 2 cases

Rafik A. Abdelsayed, Ty Sumner, Carl M. Allen, Antwan Treadway, Gregory M. Ness, Sam L. Penza

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

The development of secondary malignancies has been recognized as a potential iatrogenic complication in patients who have graft-versus-host disease secondary to bone marrow transplantation. Lymphohematopoietic cancer is most frequent, although solid malignancies have also been reported. We describe 2 patients with graft-versus-host disease who developed oral precancerous and malignant lesions. The first patient, a 24-year-old white man, had erythroplakia of the buccal mucosa that proved to be carcinoma in situ histopathologically. The second patient, a 14-year-old Hispanic boy, developed synchronous cutaneous and lingual squamous cell carcinomas. The current cases and similar sporadic case reports found in the literature highlight the susceptibility of patients with graft-versus-host disease to the development of oral cancer. Therefore, it is recommended that thorough evaluation of the oral mucosa and close follow-up be offered to all patients treated with bone marrow transplantation and particularly to those who develop graft-versus-host disease.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalOral surgery, oral medicine, oral pathology, oral radiology, and endodontics
Volume93
Issue number1
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

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