Oral precancerous and malignant lesions associated with graft-versus-host disease

Report of 2 cases

Rafik A Abdelsayed, Ty Sumner, Carl M. Allen, Antwan Treadway, Gregory M. Ness, Sam L. Penza

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The development of secondary malignancies has been recognized as a potential iatrogenic complication in patients who have graft-versus-host disease secondary to bone marrow transplantation. Lymphohematopoietic cancer is most frequent, although solid malignancies have also been reported. We describe 2 patients with graft-versus-host disease who developed oral precancerous and malignant lesions. The first patient, a 24-year-old white man, had erythroplakia of the buccal mucosa that proved to be carcinoma in situ histopathologically. The second patient, a 14-year-old Hispanic boy, developed synchronous cutaneous and lingual squamous cell carcinomas. The current cases and similar sporadic case reports found in the literature highlight the susceptibility of patients with graft-versus-host disease to the development of oral cancer. Therefore, it is recommended that thorough evaluation of the oral mucosa and close follow-up be offered to all patients treated with bone marrow transplantation and particularly to those who develop graft-versus-host disease.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalOral surgery, oral medicine, oral pathology, oral radiology, and endodontics
Volume93
Issue number1
DOIs
StatePublished - Jan 1 2002

Fingerprint

Graft vs Host Disease
Mouth Mucosa
Bone Marrow Transplantation
Neoplasms
Mouth Neoplasms
Carcinoma in Situ
Hispanic Americans
Tongue
Squamous Cell Carcinoma
Skin

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Oral precancerous and malignant lesions associated with graft-versus-host disease : Report of 2 cases. / Abdelsayed, Rafik A; Sumner, Ty; Allen, Carl M.; Treadway, Antwan; Ness, Gregory M.; Penza, Sam L.

In: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Vol. 93, No. 1, 01.01.2002, p. 75-80.

Research output: Contribution to journalArticle

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