Oreocnide integrifolia (GAUD.)miq exhibits hypoglycemic and hypolipidemic potentials on streptozotocin diabetic rats: A preliminary dose and duration dependent study

Ansarullah, Menaka Thounaojam, Ravirajsinh Jadeja, Ranjitsinh Devkar, A. V. Ramachandran

Research output: Contribution to journalArticle

7 Scopus citations


Oreocnide integrifolia (Gaud.)Miq (Urticaceae) leaves are used to alleviate diabetic symptoms in folk medicine in northeast India. In the present study, dose and duration dependent hypoglycemic potentials were evaluated in streptozotocin induced diabetic rats. Administration of aqueous leaf extract (100, 250, 500 and 750 mg/kg body weight orally once daily) to diabetic rats reduced glycemic levels by 56% by 4 weeks of treatment and was comparable to standard reference drug Metformin. The experimental data also revealed significant improvement in lowering lipid profile, Urea, Creatinine, Hb, HbA1c and insulin levels. The present study clearly demonstrates hypoglycemic and hypolipidemic potential of Oreocnide integrifolia leaf extract.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalEXCLI Journal
StatePublished - Dec 1 2009
Externally publishedYes



  • Insulin
  • Oreocnide integrifolia
  • Streptozotocin

ASJC Scopus subject areas

  • Molecular Medicine
  • Animal Science and Zoology
  • Pharmacology
  • Drug Discovery

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