Organism-dependent fungicidal activities of azoles

Elias K. Manavathu, Jessica L. Cutright, Pranatharthi H. Chandrasekar

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

We investigated the antifungal activities of itraconazole and voriconazole on Aspergillus species by time kill studies, and the results were compared with those obtained for Candida species. Exposure of Aspergillus fumigatus conidia to varying concentrations (1.25 to 10 μg/ml) of itraconazole and voriconazole resulted in cellular death; the cytocidal effect was time and concentration dependent. In contrast, no killing of Candida albicans occurred in the presence of itraconazole and voriconazole at concentrations as high as 10 μg/ml, although candidal growth was inhibited compared to the drug-free control. Amphotericin B (1.25 to 10 μg/ml), on the other hand, killed both A. fumigatus and C. albicans. Similar results were obtained for non-A. fumigatus aspergilli and non-C. albicans Candida species. These observations indicate that both itraconazole and voriconazole are cytocidal agents for Aspergillus species but not for Candida species, suggesting that azoles possess organism-dependent fungicidal activities.

Original languageEnglish (US)
Pages (from-to)3018-3021
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume42
Issue number11
StatePublished - Nov 1 1998

Fingerprint

Azoles
Itraconazole
Aspergillus fumigatus
Candida albicans
Aspergillus
Candida
Fungal Spores
Drug and Narcotic Control
Amphotericin B
Voriconazole
Growth

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Manavathu, E. K., Cutright, J. L., & Chandrasekar, P. H. (1998). Organism-dependent fungicidal activities of azoles. Antimicrobial Agents and Chemotherapy, 42(11), 3018-3021.

Organism-dependent fungicidal activities of azoles. / Manavathu, Elias K.; Cutright, Jessica L.; Chandrasekar, Pranatharthi H.

In: Antimicrobial Agents and Chemotherapy, Vol. 42, No. 11, 01.11.1998, p. 3018-3021.

Research output: Contribution to journalArticle

Manavathu, EK, Cutright, JL & Chandrasekar, PH 1998, 'Organism-dependent fungicidal activities of azoles', Antimicrobial Agents and Chemotherapy, vol. 42, no. 11, pp. 3018-3021.
Manavathu EK, Cutright JL, Chandrasekar PH. Organism-dependent fungicidal activities of azoles. Antimicrobial Agents and Chemotherapy. 1998 Nov 1;42(11):3018-3021.
Manavathu, Elias K. ; Cutright, Jessica L. ; Chandrasekar, Pranatharthi H. / Organism-dependent fungicidal activities of azoles. In: Antimicrobial Agents and Chemotherapy. 1998 ; Vol. 42, No. 11. pp. 3018-3021.
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