Organophosphates, serine esterase inhibition, and modeling of organophosphate toxicity

Janice E. Chambers, Seth F. Oppenheimer

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

The highlighted article in this issue (Ashani and Pistinner, "Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates Toxicity: A Mathematically Based Toxicokinetic Model") is an innovative approach to modeling the amount of protective enzyme, human butyrylcholinesterase, that could be administered to humans to protect them from the lethal effects of organophosphate nerve agents. The threat of nerve agent exposures at lethal levels regrettably remains a threat to military as well as civilian populations, and the authors of this article have used their previous experimental data along with new in vitro data to devise and calibrate a mathematical model that could have practical utility in the prophylaxis of military personnel against chemical warfare agents.

Original languageEnglish (US)
Pages (from-to)185-187
Number of pages3
JournalToxicological Sciences
Volume77
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology

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