TY - JOUR
T1 - Osteoarthrosis of the temporomandibular joint following experimental disc perforation in Macaca fascicularis
AU - Helmy, Emad
AU - Bays, Robert
AU - Sharawy, Mohamed
N1 - Funding Information:
* PhD student, Department of Oral Biology/Anatomy, Medical College of Georgia, Augusta. t Professor and Chairman, Department of Oral and Maxillofacial Surgery, Emory University, Atlanta. $ Professor and Chairman, Department of Oral Biology/ Anatomy, Medical College of Georgia, Augusta. This study was performed while Dr Helmy was a Peace Fellow in the Department of Oral Biology/Anatomy, Medical College of Georgia. Supported in part by Amideast Company grant #IO-12-02-1122-64. Address correspondence and reprint requests to Dr Sharawy: Department of Oral Biology/Anatomy, Medical College of Georgia, Augusta, GA 30912.
PY - 1988/11
Y1 - 1988/11
N2 - The aim of this experiment was to study the sequela of experimental temporomandibular joint (TMJ) disc perforation. Each TMJ of four Macaca fascicularis adult monkeys was surgically exposed, and a 4- to 6-mm perforation at the posterolateral portion of the avascular disc was produced by electrosurgery. Four monkeys were used as controls. The animals were killed 11 weeks (two experimental and two controls) or 12 weeks (two experimental and two controls) after disc perforation. The perforations were increased in size in five joints, and healed in one joint. In addition, two joints of one animal showed complete loss of the disc, denudation of articular surfaces, and bone-to-bone contact. In contrast to control joints, the experimental joints exhibited the following changes histopathologically: thick, highly cellular and fibrillated fibrous coverings of articular surfaces (five joints); marked hyperplasia of synovial membrane; migration of synovial cells on the surfaces of the disc and margins of perforation; multiple adhesions of disc to articular surfaces; increase in cellularity and vascularity of discs; and chondrocytic clustering in temporal fibrous covering; and osteophytes of condylar and temporal components and focal or complete denudation of articular surfaces (2 joints). Most of these changes were consistent with the diagnosis of osteoarthritis. From this study, one can conclude that disc perforation can lead to osteoarthritis.
AB - The aim of this experiment was to study the sequela of experimental temporomandibular joint (TMJ) disc perforation. Each TMJ of four Macaca fascicularis adult monkeys was surgically exposed, and a 4- to 6-mm perforation at the posterolateral portion of the avascular disc was produced by electrosurgery. Four monkeys were used as controls. The animals were killed 11 weeks (two experimental and two controls) or 12 weeks (two experimental and two controls) after disc perforation. The perforations were increased in size in five joints, and healed in one joint. In addition, two joints of one animal showed complete loss of the disc, denudation of articular surfaces, and bone-to-bone contact. In contrast to control joints, the experimental joints exhibited the following changes histopathologically: thick, highly cellular and fibrillated fibrous coverings of articular surfaces (five joints); marked hyperplasia of synovial membrane; migration of synovial cells on the surfaces of the disc and margins of perforation; multiple adhesions of disc to articular surfaces; increase in cellularity and vascularity of discs; and chondrocytic clustering in temporal fibrous covering; and osteophytes of condylar and temporal components and focal or complete denudation of articular surfaces (2 joints). Most of these changes were consistent with the diagnosis of osteoarthritis. From this study, one can conclude that disc perforation can lead to osteoarthritis.
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U2 - 10.1016/0278-2391(88)90335-7
DO - 10.1016/0278-2391(88)90335-7
M3 - Article
C2 - 3183809
AN - SCOPUS:0023756929
SN - 0278-2391
VL - 46
SP - 979
EP - 990
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
IS - 11
ER -