TY - JOUR
T1 - Osteoinduction in Rhesus Monkeys using demineralized bone powder allografts
AU - Hosny, Mahmoud
AU - Sharawy, Mohamed
N1 - Funding Information:
From the Department of Oral Biology and Anatomy, School of Dentistry, Medical College of Georgia, Augusta, GA 30912. (Dr. Hosny is currently a resident in the Department of Oral and Maxillofacial Surgery, Tufts University, Boston, Massachusetts.) This study was performed while Dr. Hosny was a Peace Fellow in the Department of Oral Biology/Anatomy. The work was partially supported by an Amideast Company Grant No. 10-12-02-1122-63. A portion of this study was presented at the 1984 Annual Meeting of the American Association of Oral and Maxillofacial Surgeons. Address correspondence and reprint requests to Dr. Mohamed Sharawy.
PY - 1985/11
Y1 - 1985/11
N2 - This experiment tested the osteoinductivity of demineralized bone powder (DBP) in nonhuman primates. Six DBP implants were implanted subcutaneously close to the pectoralis major muscle in each of four rhesus monkeys. Excisional biopsies were obtained 20, 40, and 72 days after implantation and were processed for light and electron microscopy. Decalcified and undecalcified sections of the implants were studied. Large numbers of undifferentiated mesenchymal and fibroblast-like cells were observed around and within the DBP matrix particles on day 20. Cartilage formation was also evident at that time and had increased by day 40, when chondroid bone also appeared. By day 72, the implants showed mature (lamellar) and immature (woven and chondroid) bone and bone marrow formation. Areas of DBP that were incorporated within the induced bone contained empty lacunae and stained similarly to mineralized bone. It was concluded that allogenic DBP can induce bone formation in monkeys. The results justify the use of DBP as a bone-banked material to induce bone formation in humans.
AB - This experiment tested the osteoinductivity of demineralized bone powder (DBP) in nonhuman primates. Six DBP implants were implanted subcutaneously close to the pectoralis major muscle in each of four rhesus monkeys. Excisional biopsies were obtained 20, 40, and 72 days after implantation and were processed for light and electron microscopy. Decalcified and undecalcified sections of the implants were studied. Large numbers of undifferentiated mesenchymal and fibroblast-like cells were observed around and within the DBP matrix particles on day 20. Cartilage formation was also evident at that time and had increased by day 40, when chondroid bone also appeared. By day 72, the implants showed mature (lamellar) and immature (woven and chondroid) bone and bone marrow formation. Areas of DBP that were incorporated within the induced bone contained empty lacunae and stained similarly to mineralized bone. It was concluded that allogenic DBP can induce bone formation in monkeys. The results justify the use of DBP as a bone-banked material to induce bone formation in humans.
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U2 - 10.1016/0278-2391(85)90219-8
DO - 10.1016/0278-2391(85)90219-8
M3 - Article
C2 - 3903081
AN - SCOPUS:0022378884
SN - 0278-2391
VL - 43
SP - 837
EP - 844
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
IS - 11
ER -